Clinical Study On Treatment Of Malignant Ascites With Wenyanglishui Prescription Acupoint Application

Objective:To observe the therapeutic effect of wenyanglishui prescription acupoint application on the clinical symptoms of patients with malignant ascites and its impact on the quality of life,so as to provide theoretical basis and clinical data support for the clinical application of wenyanglishui prescription acupoint application to improve the clinical symptoms of patients with malignant ascites and improve the quality of life.Methods:In this study,50 inpatients in oncology department of suzhou traditional Chinese medicine hospital from March 2019 to January 2020 were collected and randomly divided into control group and experimental group with 25 patients each.Patients in the control group were given routine symptomatic supportive treatment and oral conventional diuretic therapy(antisol 40mg+furosemide 20mg,bid)according to their condition.(The patients were treated with albumin<20g/L,or lOg of serum albumin qd).On this basis,the experimental group combined with wenyanglishui prescription acupoint application,replaced the patch once a day.Observed and recorded the general data of the two groups before and after treatment,ascites maximum depth,flat navel abdominal circumference,24h urine volume,body weight,urine weight ratio,KPS and ZPS,TCM symptom score,skin adverse reaction,blood routine,liver and kidney function,hemagglutination index,serum albumin and other safety indexes.Finally,statistical analysis was carried out to evaluate its efficacy and safety.Results:50 cases were included in this study,5 cases were removed,and 45 cases were actually completed,including 22 cases in the experimental group and 23 cases in the control group.?The maximum depth of ascites:the maximum depth of ascites before and after treatment in the experimental group was compared,P<0.05.The difference was statistically significant,and the control group was compared before and after,P>0.05.The difference was not statistically significant.?Effective ascites:The effective control rate of the experimental group was 90.9%,and that of the control group was 78%,P>0.05.The difference was not statistically significant.? Maximum flat umbilical abdominal circumference:comparison of flat umbilical abdominal circumference before and after treatment in experimental group,P<0.01,the difference was statistically significant.The control group was compared before and after treatment,P<0.05,and the difference was statistically significant.?24h urine volume:24h urine volume was compared between the two groups before and after treatment,and the P<0.01.The difference was statistically significant,and the experimental and the control group were compared after treatment,P<0.05,and the difference was statistically significant.?KPS and efficiency:The KPS of the two groups after treatment,P<0.05,the difference was statistically significant.The experimental group before and after,P<0.05,the difference was statistically significant;the effective improvement rate of the experimental group was 41%,and the effective improvement rate of the control group was 22%,P>0.05.The difference was not statistically significant.?ZPS:ZPS comparison before and after treatment in experimental group,P<0.01.The difference was statistically significant.?Single score of TCM symptoms:the experimental group and the control group had a significant improvement in eating less anorexia,P<0.05.The difference was statistically significant;there was no significant difference in abdominal distention,abdominal pain,fatigue,chills,cold limbs,abdominal veins,etc.?Total score of TCM symptoms and total curative effect:the total score of TCM symptoms after treatment in the two groups was compared,P<0.01,the difference was statistically significant,and the difference was statistically significant in the experimental group before and after treatment,P<0.01.The effective control rate in the experimental group was 55%,and the effective control rate in the control group was 13%,P<0.01,and the difference was statistically significant.?Safety index:before and after treatment,the two groups were tested on blood routine,liver function,kidney function,electrolyte,coagulation function,serum albumin and other indexes,P>0.05,and the difference was not statistically significant.?Adverse Reactions:the experimental group did not have skin adverse reactions associated with this study during the treatment.Conclusion:?Wenyanglishui prescription acupoint application has obvious effects inreducing ascites volume and abdominal circumference,increasing urine output,improvingquality of life,physical condition and TCM symptoms.?The treatment method is simple andconvenient,with strong operability,less adverse reactions and high safety,which is worthy offurther clinical research.