| Objective: Liver cirrhosis caused by hepatitis B virus is a chronic, degenerative disease in which normal liver cells are damaged and are then replaced by scartissue. Liver Cirrhosis changes the structure of the liver and the blood vessels that nourish it. Ascites is the commonest clinical manifestation in cirrhosis decompensation stage. About 75% patients can emerge ascites, and the modern medicine can not control the progress of disease effectively. There are many reports saying that the Traditional Chinese Medicine(TCM) and the Chinese herbal medicine can get good effects in healing liver cirrhosis with ascites caused by hepatitis B virus.With the guidance of the theory of TCM, combination TCM endotherapy with application treatment, we observe the changes of amount in test and the clinical symptoms score. The effect and mechanism of Xiaogu Decotion and Lishui Patch on liver cirrhosis with ascites were investigated so as to provide experimental data.Methods: By sign informed consent form,we chosed 80 patients of liver cirrhosis with ascites who were in the third hospital of Hebei Medical University since 2008-1 and completed the collection of clinical data. We divided them into two groups randomly.40 cases were in the treated group,and 40 cases in the control group.There were not significant difference in two groups. The treated group and the control group accepted same treatment of the foundation(including general treatment and symptomatic treatment).In the foundation,the treated group was treated by Xiaogu Decotion and Lishui Patch.The treatment course is two months.We observe clinic symptom scores before and after treatment, objective sign, complicating electrolyte disturbances, abdominal circumference,weight, urine volume in 24h, sedes frequency, diuretic dosage, colloid dosage,abdominal ultrasound abdominocentesis and so on. All the data were collected for statistical analysis. Results:1 All the patients completed this experiment on time and followed up for six months.2 General therapeutic effect: The total effective rate was 95.00% in the treated group which was much higher than 80.00% in the control group(P<0.05).3 The curative effect of symptom had significant difference after treatment in two groups,and the treated group surpassed the control group(P<0.05). In the treated group,clinic symptom integral had significant difference comparing before treatment(P < 0.05).After treatment,compared with the control group,clinic symptom had significant difference in the treated group(P<0.05).4 The usage amount of diuretic had significant difference after treatment in two groups,and the treated group is less than the control group(P<0.05).5 The treated group is less than the control group in the number of people with colloid(P<0.05).Compared with colloid dosage in two groups,the treated group is less than the control group(P<0.05).6 Compared with abdominocentesis in two groups,the treated group is less than the control group(P<0.05).7 Compared with liver function in control group,the treated group was significant difference according to statistic analysis(P < 0.05).And the difference between the before and the after treatment were also apparent(P<0.05)in two groups respectively.8 The improvement of hepatic fibrosis in treated group was better than that in control group,which has significant difference between two groups according to statistic analysis(P<0.05).And the difference between the before and the after treatment were also apparent (P<0.05) in two groups respectively.9 There was no significant difference in abdominal ultrasound between the two groups(P>0.05).10 The complication after the treatment:Two groups had markly difference in the complicating electrolyte disturbances cases,especially in hypopotassaemia.11 Compared with the ascites regression time,the treated group was shorter than the control group(P>0.05).12 Rehospitalization after six months:Rehospitalization of 4 patients in the treated group was markly difference from rehospitalization of 10 patients in the control group(P<0.05).13 There was no abnormality before and after the treatment in two groups in blood routine,urine routine,renal function and myocardial enzyme.Conclusion:1 The findings prompted that the combination use Xiaogu Decotion and Lishui Patch with medicine conventional therapy can obviously improve the symptom,physical sign,liver function and serum fibrosis index of the patients of liver cirrhosis with ascites caused by hepatitis B virus. Xiaogu Decotion and Lishui Patch is an effective method for treatment of liver cirrhosis with ascites caused by hepatitis B virus. Xiaogu Decotion and Lishui Patch is an effective drug for treatment of liver cirrhosis with ascites caused.2 The Xiaogu Decotion and Lishui Patch decrease length of stay,and lessen the cost of therapy.We did not find any adverse effect obviously.Although further research is required to explore these mechanisms,the Xiaogu Decotion and Lishui Patch will supply better methods for liver cirrhosis with ascites caused by hepatitis B virus.
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