Study On The Characteristics Of TCM Constitution, Syndrome And Facial Skin Lesions In Patients With Delayed Acne

[Objective]Through the investigation about the skin lesions degree of late-onset acne patients,the distribution of facial lesions and the constitution of Traditional Chinese Medicine,as well as and the distribution of TCM syndromes,to summarize the characteristics and regularity of facial skin lesions of late-onset acne and to provide basis for differential diagnosis of late-onset acne and acne vulgaris;based on the constitution differences of the patients,to find the potential susceptible constitution of late-onset acne,establish late-onset acne susceptible population survey;to conclude the TCM syndromes characteristics of late-onset acne patients,to explore relationship between the distribution of TCM syndromes and the distribution of acne,to discuss whether there are acne distribution differences between the patients with different syndromes;to find out the relationship between skin lesions and skin lesions distribution;to establish the correlation between the distribution part and the five internal organs,and to provide the basis for the legislation of Chinese traditional treatment for late-onset acne.[Methods]According to the diagnostic criteria of late-onset acne,235 patients with late-onset acne were included.The clinical symptoms and facial skin lesions of 235 patients with late-onset acne were recorded,and symptoms constitution questionnaires were filled,recorded with facial area division method.According to the diagnostic criteria of "Chinese medicine new drug clinical research guidelines",TCM syndrome could be divided into four syndromes:wind-heat syndrome,damp-heat syndrome,blood stasis or phlegm condensate syndrome,and imbalance of Chong and Ren channels;Chinese medicine constitution could be divided into moderate constitution,Yang deficiency constitution,Yin deficiency constitution,Qi deficiency constitution,Qi stagnation constitution,damp-heat constitution,phlegm-damp constitution,blood stasis constitution and specific endowment constitution,total of 9 physical constitution;Pillsbury classification method was used for classifying patients' facial acne into degree ???;meanwhile,the patient's ages,genders,heights,weights,durations of disease,dietary conditions,menstruations,sleep qualities and other general situations were collected.[Results]The onset ages of late-onset acne were statistically different(P<0.05),mainly from age 25 to 29(P<0.0083),followed by 30-34(P<0.0083),and there was statistical difference between genders(P<0.05),the ratio of male and female was about 1:5.91;the average duration was 362.4681 ± 430.4413 days.The distribution of lesion severity was uneven(P<0.05),there was statistical significance in the differences between level I and ? skin lesions and other skin lesions(P<0.0083),which were mainly distributed in the renal,liver and lung areas(P<0.005).It was found in the statistics of single constitution that there were statistically significant differences in the constitution distribution of late-onset acne;compared with other physical constitution,the differences of damp-heat constitution,Yang deficiency constitution,phlegm-damp constitution,moderate constitution,Yin deficiency constitution,Qi deficiency constitution were statistically significant(P<0.00139).In the statistics of concurrent constitutions,compared with other physical constitution,the differences of damp-heat constitution,Yang deficiency constitution,phlegm-damp constitution were statistically significant(P<0.00139).In the aspect of syndromes,damp-heat syndrome and imbalance of Chong and Ren channels syndrome dominated(P<0.0083),accounting for 34.0%and 29.4%.It could be found respectively from the statistics that the average duration of damp-heat syndrome was 282.89±419.91 days,the difference between level ? skin lesion and other skin lesions had statistical significance(P<0.0083),and the difference between the renal area and the liver area and other skin lesions was statistically significant(P<0.005).The duration of the patients with imbalance of Chong and Ren channels syndrome was 391.16±389.62,there was statistical significance in the differences between level I and ? skin lesions and other skin lesions(P<0.0083),there was no statistical significance in the differences between renal area,liver,lung area and other distribution parts(P<0.0083).Physical constitutions of the patients in two groups were mainly damp-heat constitution,but no specificity(P<0.005).Logistic regression analysis was made to the patients with damp-heats syndrome,and it could be found that the duration of disease,lung area distribution and damp-heat syndrome were negatively correlated(P<0.05).There was a positive correlation between the degree of skin lesion and the damp-heat syndrome(P<0.05);according to logistic regression analysis of the late-onset acne with imbalance of Chong and Ren channels syndrome,the degree of skin lesions was negatively correlated with imbalance of Chong and Ren channels syndrome(P<0.05).[Conclusion]The onset age of late-onset acne is 25-29 years old,followed by 30-34 years old.The severity of skin lesions are mainly level ? and ?,mainly distributed in the kidney and liver,lung area.In single physical constitution research,the late-onset acne were mainly damp-heat constitution,Yang deficiency constitution,phlegm-damp constitution,moderate constitution,Yin deficiency constitution,Qi deficiency constitution,and in the statistics of concurrent constitution,mainly damp-heat constitution,Yang deficiency constitution,phlegm-damp constitution;it could be concluded that damp-heat constitution,Yang deficiency constitution,phlegm-damp constitution are susceptible constitution for late-onset acne;As for the aspect of syndromes,late-onset acnes are mainly damp-heat syndrome,imbalance of Chong and Ren channels syndrome;the average disease duration of patients with damp-heat syndrome is short,mainly level I and II and distributed in the renal and liver area.The average duration of patients with imbalance of Chong and Ren channels syndrome is relatively long,mainly level I and II,and distributed in the renal,liver and lung area;Patients in two groups mostly have damp-heat constitution;damp-heat syndrome and the duration of disease are positively correlated;damp-heat syndrome is negatively correlated with the duration of disease and lung area distribution,and positively correlated with the degree of lesions;imbalance of Chong and Ren channels is negatively correlated with the degree of lesions.