Study On The Cardiac Fatigue Of The Exhausted Swimming In Rabbits With PCG And ECG

Fatigue heart description of cardiac function in a temporary drop in a state and fatigue heart to a broader population, like white-collar gens for a long time in the office of the high pressure and long time will let their heart for a long time in a state of stress, heart often time under the stimulation of tensioning work will emerge in a state of fatigue; and is a cardiac fatigue is more likely to crowd of athletes, athletes because improve athletic performance often uses the high load training, such training often because of high intensity, long the heart burden larger and therefore more prone to heart of fatigue. Fatigue heart just to cardiac dysfunction of a temporary state, the cardiac function decreased if get timely adjust and resting cardiac function can be restored; however heart fatigue unlike skeletal muscle fatigue so easy to people's perception, fatigue heart to not arouse people's attention, fatigue heart if the heart to stimulated by high intensity, fatigue heart state not ease the long-term accumulation of fatigue heart may to overwork or even damage the change. The heart is the center of human nutrition, the heart is too tired or myocardial injury will threaten people's life at any time, it should be the heart of fatigue caused enough attention. Due to myocardial unlike skeletal muscles that are easy to fatigue, observe cardiac fatigue is more difficult than were observed in skeletal muscle fatigue phenomenon, it is difficult to under low or medium loads observed fatigue heart, researchers often limited to high load sports competitions(such as triathlons and marathons) the opportunity to observe heart waiting for the appearance of fatigue. In addition, long time and high intensity exercise has the potential risk of sudden death not specially for studying cardiac fatigue to arrange high load exercise competition. Therefore, the establishment of rabbit swimming exhaustive experimental application of heart sound map, ECG to detect cardiac fatigue in rabbits, in order to lay the foundation for the study of cardiac fatigue. The experimental animal research of heart fatigue to overcome past international in iron man three or the marathon race in the field of high strength of heart fatigue problems, can better control the amount of exercise and individual comparability, and easily repeated experiments, the relationship between this is beneficial to the study of motor evoked heart fatigue and myocardial injury, to understand the similarities and differences of cardiac fatigue among species, is beneficial to explore the human heart fatigue law; repeated exhaustive exercise in experimental rabbits, can in a relatively short period of time to observe the experimental animal from the resting state to the fatigue state to the fatigue state and cause heart the whole process of a few animal death in response to high intensity exercise, strictly control the amount of exercise in as far as possible, at the same time PCG and ECG, explore the exercise-induced cardiac fatigue and The relationship between myocardial injury, noninvasive, universal method to detect the heart force, heart rate and rhythm changes caused by exercise load, in order to capture the phenomenon of cardiac fatigue and explore the basis of sudden cardiac death.Methods: multi wheel load swimming was carried out in the rabbit until exhaustive exercise. Electrocardiogram phonocardiogram test immediately before the concrete process of experiment: in rabbits after purchase will be a week of feeding to adapt to the environment, in the swimming to collect the quiet state of PCG and ECG data, the third time of exhaustive swimming test, each exhaustive swimming test specific operation process: each rabbit swimming every 30 seconds test immediately heart ECG data, and then rest for 3 minutes and 30 seconds swimming, swimming test data, rest 3 minutes, so the cycle until rabbits force exhaust(exhaustive definition is the rabbit head sank into the water for 2 seconds can't surfaced); swimming exhaustive rest after 2 days, the rest for 24 and 48 hours of time points(Figure 3). 2 rabbits were tested on each experimental day. In this experiment, 20 New Zealand white rabbits(experimental animal center, Medical University Of Chongqing) were selected, and the weight of 1.9-2.1km, 10 females and 10 males were selected.Experimental results show that the rabbits in the swimming straight exhaustive process, myocardial contraction ability at the beginning of exercise strengthens the heart for the body under stress provides adequate blood and nutrients contraction; along with the movement time of sustained myocardial contraction ability is abate until exhaustive myocardial has no force contraction even to heart failure. At the time of swimming, there were abnormal Q waves, ST Duan Shenggao, ventricular fibrillation and other phenomena in the electrocardiogram of rabbits. In the experimental process there are some new phonocardiogram reflect: rabbits in exhausted some will appear second heart sound hidden or alternation of strong phenomenon, corresponding to the second heart sound time and ECG T wave period, congestive heart failure, CHF patients often appear the phenomenon of T wave inversion and the second heart sound alternating with T wave inversion are closely linked, which is also a need for further experimental research. At the same time the rabbit also appeared before the death rate dips, diastolic and systolic time ratio of abnormal rising phenomenon.At the same time, there are some differences between the heart and the heart of the human body. In the study of the fatigue changes in the center of the swimming pool, the fatigue changes in the center of the heart can provide the corresponding data for the study of the human heart fatigue. Rabbits in the exhausted and death of some PCG, ECG special phenomena and data will heart from fatigue toward the transformation of the work and myocardial injury research provide a basis for future through continuous research is likely to become heart fatigue, some indicators of labor, myocardial injury and heart, and PCG and ECG detection has the advantages of no invasive, repeatability, simple operation and no side effect and is more easily spread. Combined with ECG and phonocardiogram cardiac fatigue research is not only beneficial to the athlete's heart health protection and monitoring, with the increase of continuous reports of sudden death and sub healthy people, study of fatigue heart for the heart health of the general public also has very important practical significance.