Relationship Between Carotid Plaque And Hcy,hs-CRP In Different Risk Groups Of Patients With High Altitude Stroke

Objective : Stroke is a common and frequently occurring disease in our province,which seriously threatens the health of the people.The high altitude hypoxia has a certain influence on the physiology and pathology of stroke patients.The basic research data on the prevention and control of stroke in the plateau area of our province are lack.In order to prevent the occurrence of cerebral vascular disease(CVD)in high altitude areas,this topic mainly studies the influencing factors of atherosclerosis(AS)in CVD risk population,especially the relationship between AS formation in low,middle and high risk population with serum homocysteine(Hcy),hypersensitivity C reactive protein(hs-CRP),AS formation and blood between Tibetan and Han people.To clarify the differences between Hcy and hs-CRP,to guide the standardization of diagnosis and treatment of risk factors,to provide basis for clinical prevention and intervention of carotid atherosclerotic cerebral apoplexy in plateau areas and to accumulate research data.Methods : By screening for the risk factors of stroke for more than 30 years old residents over 40 years old in Hainan,Qinghai Province,302 cases of different risk groups and informed consent were collected according to the standard of entry and exclusion.According to the technical specification for screening and intervention of high-risk population in 2014,the group was divided into low,medium and high risk groups(138,65 and 99 respectively).General related data were collected,blood glucose,blood lipid and carotid color Doppler examination were performed.The correlation between the three groups was compared and the relationship between the related factors and stroke was analyzed.Results : a total of 302 patients with different risk of stroke in Hainan were investigated,including low risk 138(45.70%),middle risk 65(21.52%),and high risk99(32.78%).Compared between the 3 groups,the serum levels of hs-CRP and Hcy and the detection rate of AS in the low,middle and high risk groups were gradually increasing,and the difference was statistically significant(P < 0.05).The proportion of Tibetans in high risk groups is higher than that of the Han nationality.The serum levels of hs-CRP,Hcy and AS in Tibetan were significantly higher than those in Han nationality(P < 0.05).Serum hs-CRP and Hcy levels in group AS were higher than those in group AS(P < 0.05).The detection level of carotid atherosclerosis is different in different risk groups at high altitude.Hypertension(HBP),dyslipidemia,diabetes(DM),atrial fibrillation / valvular heart disease(VHD),smoking,body mass index(BMI)more than 26kg/m2 or obesity,lack of exercise,the history of ACI family,previous ACI,intimal IMT thickening,and cervical AS are significant for the occurrence of stroke.The past transient ischemic attack(TIA),neck movement There was no significant statistical significance in the stenosis or occlusion of the veins.Conclusion : 1.high altitude environment leads to increased risk of stroke,and the onset age of high altitude cerebrovascular disease is earlier than that of plain area.2.the serum Hcy and hs-CRP of Tibetan group at the same altitude are higher than those of Han nationality.3.the occurrence of carotid plaques was significantly correlated with serum Hcy and hs-CRP levels.