Cross-sectional Study On Depression In Pregnant Women And Correlation Between Leptin And Postpartum Depression

Objective To understand the prevalence of depression in pregna nt women and its in-fluencing factors,and to analyze the relationship between maternal serum leptin levels and postpartum depression,aiming to further explore the biological mechanism of postpartum de-pression,which provides reference for understanding and prevention of postpartum depres-sion.Methods(1)Cross-sectional study of depression in pregnant women:a cluster sampling method was used to select pregnant women after 28 weeks and waiting for production in hospital,which were total of 1202 people in N ingxia Medical University General Hospital,Yinchuan First People's Hospital,Yinchuan C ity Maternal and C hild Health Hospital,Yinchuan C ity Third People's Hospital,Wuzhong C ity First People's Hospital and Zhongwei C ity Hospital,The prenatal of depressive symptoms were assessed using the Self-rating Depression Scale(SDS).(2)Correlation study between leptin and postpartum depression:Select ing 200 Puer-peras in Yinchuan Maternal and Child Health Hospital and C hinese medicine hospital of Zhongwei C ity,Postpartum depression was assessed using the Edinburg Postnatal Depression Scale(EPDS).The 3 day postpartum woman filled out the questionnaire by herself,and the42 day postpartum adopted telephone follow-up.EPDS scores?13 points was Selected as depressive group and EPDS scores<13 points as control group within 3 days and 42 days postpartum.Applicating of enzyme-linked immunoassay(ELISA),the serum leptin levels were measured in the two groups and the relationship between leptin and postpartum depres-sion was analyzed.Results(1)The results of Cross-sectional study with depression of pregnant females were as fo l-lows:The average score of SDS was(48.29±11.11)points,which was higher than the national norm(41.88±10.57)points,the difference was statistically significant(t=21.975,P<0.001).There was a significant difference in SDS scores across levels of education(F=7.749,P<0.001).Engaging in physical workers higher than mental workers in SDS score,there was a significant difference(t=-5.828,P<0.001).The prevalence of depression was 44.6%(536/1202)in 1202 pregnant women,mild depression accounted for 67.1%,moderate depres-sion accounted for 29.9%and severe depression accounted for 3.0%.There was a significant difference in different ages among the prevalence of depression in pregnant women(?~2=7.986,P<0.05).There was a statistically significant difference in different educational levels among the prevalence of depression(?~2=27.562,P<0.001).The prevalence of depression in physical workers higher than mental workers,the difference was statistically significant(?~2=28.195,P<0.001).Multivariate non-conditional logistic regression showed that low educa-tional level(OR=0.713,95%CI:0.624~0.816)and negative life events(OR=1.721,95%CI:1.230~2.409)were risk factors for depression in pregnant women.(2)Correlation between leptin and postpartum depression:Serum leptin content was(0.37~12.22)ug/l,the average level of leptin was(1.77±1.30)ug/l for 161 pregnant women,the leptin content of depression group was(1.44±0.39)ug/l and the control group was(1.88±1.46)ug/l within 3 days postpartum,the depression group was obviously lower than the control group for leptin content,the difference was statistically significant(t=3.022,P=0.003).The leptin content of depression group was(1.19±0.18)ug/l and the Control group was(1.86±1.37)ug/l within 42 days postpartum,The depression group was also obviously lower than the control group for leptin content,the difference was statistically significant(t=5.573,P=0.001).Pearson analysis showed that:the scores of EPDS was negatively correlat-ed with serum leptin whithin 3 days postpartum(r=-0.139,P<0.05),the scores of EPDS was negatively correlated with serum leptin whithin 42 days postpartum(r=-0.168,P<0.05).Multivariate logistic regression analysis showed that higher serum leptin levels(OR=0.008,95%CI:0.001~0.118)were the protective factors of postpartum depression.Conclusion(1)The prevalence of depression in pregnant women was higher(42.8%)and the major-ity was mild depression(67.1%).(2)The degree of education and negative life events are related to the prevalence of de-pression in pregnant women,the risk factors of postpartum depression was low educational level and negative life events.(3)The depression group was obviously lower than the control group for leptin content at 3 days postpartum and 42 days postpartum,and the differences were statistically significant;the serum leptin level was negatively correlated with EPDS scores at 3 days postpartum and42 days postpartum;multivariate logistic regression analysis showed that high serum leptin levels are protective factors for postpartum depression,leptin may be related to postpartum depression.