The Relationship Between Vitamin D Level And Diabetic Nephropathy In Middle-aged And Elderly Individuals

Objective To investigate the nutritional status of 25-hydroxyvitamin D in middle-aged and elderly diabetes mellitus,and to analyze its relationship with diabetic nephropathy.Methods Based on the "REACTION" gansu region of baseline data,a total of 2178 diabetic residents was chosen as the research object to extract related content of the questionnaire,physical examination and biochemical testing project.The nutritional status of vitamin D was divided into the serum 25 OHD level: vitamin D deficiency group(25OHD < 20ng/ml),vitamin D deficiency group(20ng/ml ? 25 OHD < 30ng/ml),vitamin D sufficient group(25OHD ? 30ng/ml);According to the determination of single rick urine specimen of urine albumin and urine creatinine ratio(ACR)will DM patients are divided into: normal albuminuria group(ACR < 30 mg/g),microalbuminuria group(30 mg/g ? ACR < 300 mg/g),a large number of albuminuria group(ACR ? 300mg/g)to analyze the nutritional status of vitamin D and its correlation with diabetic nephropathy.Results(1)Among the diabetic residents enrolled in this study,including 820 males(37.6%)and females(62.4%)aging 40 to 75 years old,an average of(60.9±8.1);The average BMI was24.85 ± 3.28kg/m2.(2)The average level of serum 25 OHD in the study subjects was 16.62 ±7.93ng/ml,The prevalence of vitamin D deficiency(25OHD < 20ng/ml),lacking(20 or less than25 OHD < 30ng/ml),adequacy(25OHD ? 30ng/ml)were 74.0%,23.2%,2.8% respectively.The prevalence of vitamin D deficiency in men was significantly lower than that of women(63.4% vs.80.3%,P < 0.001).(3)The research object,the diabetes nephrosis patient's vitamin D deficiency rate was 79.7%.compared with normal albuminuria group,the average age of the diabetic nephropathy group is bigger with higher FPG,2 HPG,HbA1 c,blood lipid(TC,TG)levels and SBP,and glomerular filtration rate and serum 25 ohd levels significantly decreased(P < 0.05).(4)Partial correlation analysis showed that ACR,e GFR,DN and 25 OHD were both negatively correlated,and the correlation coefficient was-0.044,-0.071 and-0.061(P < 0.05),but no significant correlation was found between Crea and 25OHD(P=0.218).(5)Logistic regression analysis showed that: set non-lack of vitamin D(25OHD ? 20ng/ml)OR as a reference,theprevalence of diabetic nephropathy as dependent variable,vitamin D deficiency group of diabetic nephropathy risk increase(OR = 1.447,P = 1.447)with adjustment only for age and sex;On the above basis,after adjusting BMI,SBP,FPG,2hPG,HbA1 c,TC and TG,vitamin D deficiency can still increase the risk of diabetic nephropathy(OR=1.405,P=0.003).Finally,vitamin D deficiency can still increase the risk of diabetic nephropathy(OR=1.392,P=0.004)with further removal of hypertension,smoking and other factors.Conclusion Vitamin D deficiency is associated with diabetic nephropathy,Vitamin D deficiency can increase the risk of diabetic nephropathy and is an independent risk factor for diabetic nephropathy.