Association Between Two Gene Promoter Polymorphisms Of Interleukin-18 And Coronary Artery Disease: A Systemic Review And Meta-analysis

Multiple epidemiological studies have evaluated the association between interleukin(IL)-18 promoter 607C/A and 137G/C polymorphisms and the risk of coronary artery disease(CAD),but a clear consensus has yet to be established.The present meta-analysis was performed to investigate the relationship between IL-18 promoter 607C/A and 137G/C polymorphisms and the risk of CAD.An electronic search was performed to identify case–control studies evaluating the relationship of IL-18 promoter 607C/A and 137G/C polymorphisms and the risk of CAD from PubMed,Embase,Web of Science and Sciencedirect databases up to February26,2017.And reference lists of identified articles were manually searched.Pooled odds ratio(ORs)for the association and the corresponding 95% confidence intervals(CIs)were evaluated by a random or fixed-effect model.Allele A of IL-18 607C/A polymorphism was found to be significantly associated with CAD only in Asians(OR = 0.628,95%CI = 0.533 to 0.740,P =0.000),but not in Caucasians(OR = 0.950,95%CI = 0.803 to 1.124,P = 0.548).The AA/CA genotypes of IL-18 607C/A polymorphism was significantly inversed with risk of CAD(OR =0.431,95%CI = 0.326 to 0.570,P = 0.000).While no association between IL-18 607C/A Polymorphism and CAD in Caucasians in all the genetic models.However,no significant association between 137G/C polymorphism and risk of CAD was found whenever in Asians(C vs.G,OR = 0.843,95% CI = 0.577–1.231)or Caucasians(C vs.G,OR = 1.071,95% CI =0.807–1.421).Our present study suggests that IL-18 gene promoter 607 A polymorphism is a protective factor for CAD only in the Asian,while 137 C polymorphism has no protective properties.Still,a larger number of studies with large scale and sufficient original information are required to further confirm our findings.