Meta-analysis Of The Association Between ABCA1,CETP Polymorphisms And Coronary Artery Disease

background and objectiveAccording to the world health organization reports that Cardiovascular disease(CVD)have been in the top ten leading cause of death in the past decade.Lipid abnormalities are the most dangerous risk factors of Atherosclerotic heart disease.Genes involved in lipid metabolism pathways have been widely considered vulnerable to atherosclerotic heart disease.Genes involved in lipid metabolism was reported a significantly risk of coronary artery disease in other studies.But contradictory and inconsistent results were also reported among those studies.The inconsistency of findings is related to many factors,such as racial,sample sizes,methods and technical means,ect.At present,the research on genes involved in lipid metabolism associated with coronary heart disease were carried out in Caucasian.The study was aim at evaluating the relationships of ABCA1 rs2230806,CETP rs708272,CETP rs5882,CETP rs151800775 and coronary artery disease.MethodsWe use the computer retrieval and manual retrieval.A systematic literature search was conducted by Pubmed database before August 2016.The exclusion criteria was evaluated,and we strictly abide by the inclusion criteria to filter literature.The data extraction form was made and extract data was from the eligibled literature.Using statistical analysis software stata12.0(StataCorp,College Station,TX,USA)to collect and analyze data from eligibled literature.ResultsA total of 75 studies from 50 articles included in our study,which were in consistent with hardy weinberg equilibrium.According to the results of meta analysis:1.The strongest association was observed between ABCAl rs2230806 and CAD under the allelic model(G vs.A,OR=1.128,95%CI:1.018-1.249,P=0.022)and the recessive mode(GG vs.AG+AA,OR=1.164,95%CI:1.043-1.298,P= 0.006)in overallpopulation.The results also showed that significant association between ABCA Irs2230806 and CAD under the allelic model(G vs.A,OR = 1.232,95%CI:1.115-1.360,P= 4.05E-05),the homozygous model(GG vs.AA,OR = 1.425,95%CI:1.066-1.905,P= 0.017)and the recessive mode(GG vs.AG+AA,OR=1.298,95%CI:1.156-1.458,P= 1.02E-05)in Caucasian population.2.The strongest association was observed between CETP rs708272 and CAD under the allelic model(G vs.A,OR? 1.170,95%CI:1.105-1.239,P=6.19E-08),the homozygous model(GG vs.AA,OR = 1.373,95%CI:1.224-1.540,P= 6.30E-08),the recessive mode GG vs.AG+AA,OR = 1.177,95%CI:1.116-1.241,P=1.49E-09)and the dominant model(GG+AG vs.AA,OR = 1.229,95%CI:1.152-1.312,P= 4.71E-10)in overall population.3.The meta-analysis indicated that CETP rs1800775 was modestly associated with CAD under the recessive mode in Caucasian population(CCvs.CA+AA,OR =1.217,95%CI:1.069-1.385,P=0.003).4.No significant association was found between CETP rs5882 and CAD in any population.ConclusionsABCAl rs2230806 gene might be predisposed to CAD under allelic and recessive model,especially in the Caucasus.CETP rs708272 was associated with CAD.And CETP rs1800775 was modestly associated with CAD under the recessive mode in Caucasian population.CETP rs5882 was not associated with CAD in our study.