Analysis Of Pulmonary Infection And Clinical Risk Factors In Patients With Severe Hepatitis

Objectives:1.To study the basic situation,pathogenic bacteria,influencing factors and prognosis of severe hepatitis patients complicated withpulmonary infection.2.To explore the clinical risk factors of severe hepatitis complicated with pulmonary infection.Methods:In this study,pulmonary infection in severe hepatitis patients admitted to the First Affiliated Hospital of Nanchang University in December January 2015 ~2017was retrospectively analyzed.According to the diagnosis standard of severe hepatitis and pulmonary infection,518 cases of severe hepatitis(including 259 cases of infection group and non infection group)were recorded,and the clinical data and prognosis of patients were collected and analyzed.Results:1.The incidence of pulmonary infection in patients with severe hepatitis was23.08%,and the prognosis of severe hepatitis patients with pulmonary infection was poor.2.51 strains of pathogenic bacteria were isolated from the sputum of the infected group,including fungi,Klebsiella pneumoniae,Escherichia coli,Enterobacter cloacae and Enterococcus faecium.3.The clinical manifestations of the infection group were atypical,with the highest incidence of fever being 79.53%.4.Hospitalization time,hepatorenal syndrome,invasive operation,hormone therapy and Child-Pugh classification are independent risk factors for severe hepatitis complicated with pulmonary infection(P<0.05).Conclusion:Pulmonary infection is more common in many complications of patients with severe hepatitis.High incidence,complicated pathogenic bacteria and various influencing factors make pulmonary infection a "stumbling block" for therehabilitation of patients with severe hepatitis.Therefore,it is necessary to actively prevent and monitor the occurrence of pulmonary infection and control the progress of pulmonary infection in time and effectively.First of all,severe hepatitis patients should avoid invasive operation,use renal toxic drugs and immunosuppressants carefully,shorten the patient's hospitalization time as far as possible,and reduce the incidence of pulmonary infection.Secondly,for patients with pulmonary infection,the X-ray or CT examination of the lung should be improved as soon as possible,and early diagnosis should be made to reduce the incidence of missed diagnosis.Finally,sputum culture should be carried out for the patients with lung infection.The pathogenic bacteria should be identified and targeted antimicrobial therapy should be carried out according to the results of drug sensitivity.