| BackgroundAbout 240 million people worldwide are infected with chronic hepatitis B virus.About 93 million people in our country are infected with chronic hepatitis B virus.Chronic hepatitis B-Liver fibrosis–liver cancer,the trend of chronic hepatitis B development has been widely recognized.Modern medicine for the treatment of hepatitis B cirrhosis is not ideal,side effects and more difficult to stop,easy to rebound after stopping.The Chinese medicine set anti-virus,anti-liver inflammation,anti-liver fibrosis and other three aspects of treatment as a whole.Although physicians focus on the pathogenesis of cirrhosis of the liver have different emphases,but summed up the main pathogenesis of damp heat stasis for a long time,liver and spleen,spleen lost health transport,qi stagnation,blood stasis phlegm blocking network.Modern research for patients with cirrhosis or hepatitis B cirrhosis patients dialectical results are different,but dialectical results have damp syndrome.Access to literature and my previous experiments have proved that compound Huanglu oral liquid can be used for hepatitis B cirrhosis syndrome.ObjectiveTo investigate the effect of compound Huanglu oral liquid on the biochemical serology,virology and clinical symptomology of hepatitis B patients with cirrhosis and damp-heat accumulation syndrome,and to seek a better treatment for hepatitis B cirrhosis syndrome.Methods120 patients with hepatitis B cirrhosis and the syndrome of damp heat accumulationwere enrolled.On the basis of signed informed consent,120 patients were randomly divided into control group(60 cases)and experimental group(60 cases)by random number table and were treated with drugs for 48 weeks respectively.In the control group,entecavir 0.5 mg once daily was given orally.In the experimental group,the compound Huanglu Oral Liquid was added 20 mg once daily for 3 times daily on the basis of the control group.Hepatitis B E antigen,hepatitis B virus,hyaluronic acid,type III procollagen and type IV collagen were detected before treatment,24 weeks after treatment and 48 weeks after treatment.TBIL,ALB and CHE levels were measured before and 12 weeks after treatment.The liver stiffness measurement(LSM)was measured with FibroTouch before treatment,24 weeks of treatment,and 48 weeks of treatment.The symptoms and signs of the patients were observed before treatment and every 24 weeks after treatment,and scores were scored according to TCM symptoms and quantitative criteria,and then the curative effect was evaluated.All information and data were set up in the Excel database.Two people independently input and verify the data.Statistical analysis and SPSS 15.0statistical analysis software were used.The measurement data were expressed as mean ±SD.The t-test was used to compare the data with the rate of use(%),and the difference was statistically significant at P<0.05.Results1.Before treatment,there was no significant difference in TBIL between the two groups(P> 0.05).With the increase of the course of treatment,TBIL in both groups gradually decreased.After 48 weeks of treatment,the levels of serum TBIL in both groups were significantly decreased(P<0.05).After 48 weeks of treatment,the levels of TBIL in the experimental group were lower than those in the control group(P<0.05).2.Before treatment,38 cases of HBeAg positive cases and 54 cases of HBV DNA positive cases in the control group;32 cases of HBeAg positive cases and 56 cases of HBV DNA positive cases in the experimental group.On this basis,the negative rate of HBe Ag and HBV DNA in the experimental group at 24 weeks after treatment was higher than thatin the control group,but there was no significant difference between the two groups.At 48 weeks after treatment,the negative conversion rate of HBe Ag in the experimental group was 21.88% which was higher than that of the control group(18.42%,P<0.05).The negative rate of HBV DNA was 66.07%,which was higher than 57.40% of the control group(= 4.337,P <0.05).3.Before treatment,there was no significant difference in HA,IV-C and PC?between the two groups(P> 0.05).After treatment,the levels of HA,?-C and PC? in the two groups were significantly lower than those before treatment,and the cases in the experimental group were significantly lower than those in the control group(P<0.05).4.After 24 weeks of treatment,the total effective rate of TCM syndromes in experimental group was 69.10%,while the control group was 49.06%.The experimental group was higher than the control group with statistically significant difference(P<0.05).After 48 weeks of treatment,the total effective rate of TCM syndromes in experimental group was 87.27% and that of control group was 64.15%.The experimental group was higher than that of control group with statistically significant difference(P<0.05).ConclusionIn the antiviral treatment of entecavir tablets with hepatitis B cirrhosis dampness and accumulation syndrome,the combination of compound Huangqi oral liquid can increase biochemical,virological and serological responses in patients with hepatitis B cirrhosis damp-heat accumulation syndrome,and contribute to the reversal of liver stiffness.Improve TCM symptoms.The combined compound Huangqi Oral Liquid enhances the ability of oral entecavir to treat the body to remove the virus and is worthy of clinical use. |
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