The Clinical Study On The Improvement Of Serum A?1-42 And NPY Concentration Of Vascular Cognitive Impairment Patients

Objective:To observe the effect of Tongnaoyizhi granules on serum ?-amyloid protein(A?1-42)and neuropeptide(NPY)concentration in patients with vascular cognitive impairment,and to evaluate the clinical efficacy and safety of Tongnaoyizhi granules.Methods:120 patients who met the criteria of vascular cognitive impairment were randomly divided into two groups,60 in the control group and 60 in the treatment group.Patients in the control group were treated only with western medicine for the risk factors of vascular diseases.patients in the treatment group were treated with tongnaoyizhi granules on the basis of the control group for 24 weeks.the concentrations of serum A ? 1-42 and NPY,cognitive function and daily life behavior ability scale,TCM syndrome score and the occurrence of adverse reactions were observed before and after the treatment.Result:? comparison of clinical treatment effect:before treatment,there was no significant difference between the treatment group and the control group in gender,age,basic disease,scores of cognitive scale,TCM syndrome integral and serum A?1-42 and NPY concentration(p>0.05),which was comparable;After treatment,the concentrations of serumA?1-42 in the two groups increased and the concentration of serum npy decreased,but the concentration of serumA?1-42 in the treatment group(135.22±10.146)pg/mlwas significantly higher than that in the control group(116.55±17.535)pg/m,and the concentration of serum NPY in the treatment group(123.03±10.632)pg/m was significantly lower than that in the control group(134.05±20.064)pg/ml,(p<0.05).The scores of moca,ADL,BBS,ADAS-cog and SDSVD in the two groups were decreased,but the decrease was more obvious in the treatment group than in the control group(p<0.05).? comprehensive curative effect comparison:the total effective rate of the treatment group was86.67%,the total effective rate of the control group was 36.67%,the curative effect of the treatment group was more obvious than that of the control group,the difference between the two groups was statistically significant(p<0.05);? safety index evaluation:there were no significant changes in blood,urine,feces routine,liver and kidney function,electrocardiogram,etc.during the treatment,no adverse events occurred.Conclusion:Tongnaoyizhi granule can reduce the concentration of NPY and increase the concentration of A?1-42 in serum of patients with vascular cognitive impairment,effectively improve the cognitive function of patients,improve the ability of daily life of patients,improve the symptoms and clinical symptoms of traditional Chinese medicine,and is safe and effective.