San'ao Tablet After Treatment Post-infectious-cough (Cold Attack Pulmonary Syndrome) The Clinical Efficacy And Safety Of Randomized Controlled Study

Objective Observe san'ao tablet treat infections after cough(PIC,post-infectious-cough)(cold attack pulmonary syndrome)clinical curative effect and safety indicators before and after the change,with positive medicine Compound Methoxyphenamine Capsule for comparison,further to explore the diagnosis and treatment after san'ao tabletlisted fist PIC(cold attack pulmonary syndrome)clinical efficacy and safety.MethodsUsing the random number table method random grouping,Methods 60 patients with PIC(wind cold attacking lung syndrome)in the Department of respiration of the First Affiliated Hospital of Henan University of traditional Chinese medicine(TCM)were according to random number corresponding to the divided into experimental group(n = 30)and control group(n = 30).The experimentalgroupwas given san'ao tablet,the control group wasgiven compound methoxyphenamine capsule,the course of treatment was 14 days for both groups of two.To observe two groups of patients in the medication diary card,cough symptoms and syndrome score,visual analogue scale,Leicester cough questionnaire and other indicators of quality of life and clinical efficacy of two different treatment schemes evaluation and determination;analysis and determination of two groups of patients before and after treatment of blood cellsanalysis,urine routine,liver and kidney function,twelve lead electrocardiogram,ephedra safety(heart rate,blood pressure,sweating situation),the safety of two different programs to evaluate.Data analysis was performed using Spass20.0.Results1 General information60 cases of this study,0 cases of shedding,excluding 0 cases.Cases in the two groups in gender,age,vital signs(body temperature,heart rate,respiration,blood pressure)and other baseline data were not statistically different(P>0.05),comparable.2 Clinical efficacy2.1 Cough symptoms and syndrome scoreThere was no significant difference in the clinical symptoms and complication scores between the two groups before treatment(P = 0.905),which was comparable.From the time point of view,7 days of treatment,treatment for 14 days,14 days of follow-up between the two groups and the clinical symptoms of cough and disease score than before treatment decreased,there was no significant difference in the integral group(P=0.678),with time effect(P=0.000),and there is no interaction with the drug treatment group time factor(P = 0.718).At different time points,7 days of treatment,treatment for 14 days,14 days follow-up symptom scores differences between treatment group and control group were no statistical significance(P > 0.05).2.2 Cough visual analogue scaleThere was no significant difference in the visual analogue scale between the two groups before treatment(P = 0.617),which was comparable.From the time point of view,7 days of treatment,treatment for 14 days,14 days of follow-up between the two groups of cough visual analogue score than before treatment decreased,there was no significant difference in the integral group(P=0.628),with time effect(P = 0.000),and there is no interaction with the drug treatment group time factor(P = 0.596).At different time points,7 days of treatment,treatment for 14 days,14 days follow-up visual score differences between treatment group and control group with no statistical significance(P > 0.05).2.3 Leicester Cough QuestionnaireThere was no significant difference in the Leicester cough questionnaire between the two groups before treatment(P = 0.932),which was comparable.From the time point of view,7 days of treatment,treatment for 14 days,14 days of follow-up between the two groups of cough visual analogue score than before treatment decreased,there was no significant difference in the integral group(P = 0.230),with time effect(P = 0.000),and there is no interaction with the drug treatment group time factor(P = 0.509).At different time points,7 days of treatment,treatment for 14 days,14 days follow-up questionnaire score differences between treatment group and control group with no statistical significance(P > 0.05).2.4 Comprehensive effectAfter treatment,the cure rate of the experimental group was 46.7%,the effective rate was 26.6%,the effective rate was 20%,markedly effective rate was 73.3%;while the control group was cured by the rate of 43.3%,the effective rate was 23.3%,the effective rate was 26.7%,markedly effective rate was 66.6%.According to the statistical software analysis,P value was> 0.05,the two groups of comprehensive efficacy and significant difference was not statistically significant.3 Security analysisThe test was not observed in the test drug and the control drug on bloodcell analysis,urine routine,liver and kidney function,twelve lead electrocardiogram,ephed--ra safety(heart rate,blood pressure,sweating situation)had abnormal impact index of safety,no adverse reactions and serious adverse events.Conclusion1.San'ao tablet in the treatment of post-infectious-cough(cold attack pulmonary syndrome)with positive medicine Compound Methoxyphenamine Capsule has a good curative effect,which can improve the cough,sputum,chest tightness and other clinical symptoms,reduce cough visual analogue scale,improve the life quality of patients,the curative effects of the twogroups is quite.2.San'ao tablet the treatment of post-infectious-cough(cold attack pulmonary syndrome)on the human heart function,liver function and renal function without adverse reactions,is safe.