The Role Of Serum Uric Acid And Homocysteine In Assessing The Clinical Risk Of Parkinson's Disease Complicated With Hypertension

Objective:To investigate the correlation between blood uric acid,Homocysteine(HCY)levels and Parkinson's disease(PD)with hypertension.Further assessment of serum uric acid and homocysteine may be a potential risk factor for high blood pressure in patients with Parkinson's disease,and provide a feasible theoretical basis for clinical standardization in the treatment of Parkinson's disease and hypertension.Objects and methods:The total of 636 patients with PD in the Second Affiliated Hospital of Nanchang University in October 2015 to 2017 year were collected.The remaining 375 patients were excluded from diabetes,hyperlipidemia,abnormal liver and kidney function,secondary hypertension and other patients.The patients who had not been diagnosed with hyperlipidemia and incomplete data were eliminated.Of the 286 patients with PD,116 were PD complicated with hypertension,70 males and 46 females.There were 170 cases of PD without hypertension,89 males and 81 females.At the same time,the control group chose 286 healthy patients in our hospital,including 143 males and 143 females.The levels of serum uric acid,HCY,folic acid and vitamin B12 were determined by enzyme-linked immunosorbent assay and high performance liquid chromatography respectively.The severity of PD disease was classified according to the Hoehn-Yahr staging(H-Y staging)of PD patients.The blood indexes,the length of the PD course,the severity of PD disease and the age and sex of the disease were measured.Result:1.The general data of the three groups were compared: there was no significant difference in the level of folic acid and vitamin B12 between the three groups(P>0.05)compared with the without hypertension group and the healthy control group.The difference of HCY level between the three groups was statistically significant(P < 0.05).The difference of uric acid and age between the three groupswas statistically significant.After comparison between two groups,the age was significantly different between the PD with hypertension group and the PD group(P=0.002 < 0.05).There were significant differences in uric acid in PD without hypertensive group and control group(P =0.01 < 0.05).The differences of PD length and disease staging between PD with hypertension group in PD without hypertensive group were statistically significant(P < 0.05).There was no significant difference between the two groups in sex and on the treatment of levodopa(P < 0.05).2.Whether in PD complicated with hypertension group and PD without hypertensive group,there was no significant difference in the levels of uric acid,HCY,folic acid and vitamin B12 among two groups of under 65 years old and over65 years old(P > 0.05).3.In the moderate and severe PD complicated with hypertension group,the severity of hypertension was not significantly correlated with HCY and uric acid level(P > 0.05).4.In the early and middle stage of PD,the level of HCY in patients with PD complicated with hypertension was significantly higher than that in without hypertension group,with statistical significance(P < 0.05).PD complicated with hypertension group and without hypertension group,the level of HCY in the two group of middle and late PD patients was significantly higher than that of the early patients with PD,and the difference was statistically significant(P < 0.05).5.Whether in the PD complicated with hypertension group or in the PD without hypertensive group,the blood HCY level of the patients after taking levodopa was significantly higher than that in the untreated group,and the difference was statistically significant(P < 0.05).6.In the multiple regression analysis of PD complicated with hypertension,the possible risk factors of PD complicated with hypertension were related to age,HCY level and PD disease severity.There was no significant correlation between uric acid level,sex and whether taking levodopa or not.Conclusion:1.Eld?high HCY level and severe Parkinson's disease may be a risk factor for Parkinson's disease complicated with hypertension.2.Uric acid may not be a risk factor for Parkinson's disease complicated with hypertension.