The Prevalence Of Dyslipidemia And Its Influencing Factors In The Physical Examination Population Aged 45-60 Years In Hefei

ObjectiveThis study was designed to investigate the prevalence of dyslipidemia in middle-aged and elderly?45-60 years?people of Hefei describe their distribution characteristics,explore the effects of demographic characteristics,dietary habits,physical activity intensity and general physical condition on dyslipidemia.In order to facilitate the early detection,diagnosis and treatment of dyslipidemia,prevent cardiovascular and cerebrovascular diseases and promote the goal of health.In addition,providing scientific and reliable decision-making basis for medical management department.MethodsThe sample was selected from the medical center for physical examination,Anhui Province Hospital of Armed Police Forces from December 2011 to June 2012.A one-on-one questionnaire was conducted by a trained investigator.Questionnaire includes the general demographic parameters?gender,age,education level,smoking status,drinking status,physical activity,dietary behavior etc.?,Measure and record height,weight,waist circumference?WC?,hip circumference,blood pressure of the participants.Biochemical indicators includes triglyceride,total cholesterol,low density lipoprotein cholesterol,high density lipoprotein cholesterol etc.SPSS22.0 software was used for statistical analysis.The prevalence of different characteristics of subjects was compared using the?² test,the influencing factors of dyslipidemia were screened by multivariate factors unconditional binary logistic regression model,and the regression model of various dyslipidemia were predicted by the receiver operating characteristic?ROC?curve.ResultsThe survey was eventually included in 1756 subjects?1037 males and 719 females?with the average age of them were 51.0±4.7 years,aged 45-60y.The majority?70.8%?of the participants had high school and above level of education.The proportion of people who smokers and drinkers were about 28.9%and 47.4%.The participants prevalence of dyslipidemia was 41.9%,among which the prevalence of high low-density lipoprotein cholesterolemia,low high-density lipoprotein cholesterolemia,hypertriglyceridemia and hypercholesterolemia were 14.0%,18.8%,16.6%,10.5%,respectively.There were statistically significant differences about hypertriglyceridemia?P<0.001?and low high-density lipoprotein cholesterolemia prevalence in gender?P<0.001?,moreover,the prevalence of hypertriglyceridemia and low-density lipoprotein cholesterolemia in males was higher than that females.However,the prevalence of high low-density lipoprotein cholesterolemia and hypercholesterolemia were not statistically significant.There were no significant difference in the prevalence of high low-density lipoprotein cholesterolemia,hypercholesterolemia and hypertriglyceridemia in different age groups.But the prevalence of low high-density lipoprotein cholesterolemia?P=0.044?was statistically different in different age groups,the highest prevalence of low-density lipoprotein cholesterolemia in the 50-54 year-old population,with the lowest prevalence among 55-60 years.There was a significant difference in the prevalence of low high-density lipoprotein cholesterolemia at different education level?P=0.001?,furthermore,the prevalence increased with education level.The prevalence of high low-density lipoprotein cholesterolemia?P<0.001?and hypertriglyceridemia?P<0.001?were statistically significant in different smoking status.Differences drinking status in the prevalence of hypertriglyceridemia?P<0.001?and low high-density lipoprotein cholesterolemia?P=0.001?were statistically significant.In terms of physical activity intensity,the prevalence of hypertriglyceridemia at exercise?P<0.001?,sleeping?P=0.001?and total physical activity intensity?P=0.049?were significant difference.The intensity of total physical activity was statistically significant in the prevalence of hypercholesterolemia?P=0.048?.There were statistically significant differences about low high-density lipoprotein cholesterolemia in exercise?P=0.012?and traffic?P<0.001?intensity of physical activity.Also as for eating habits,the choice of non-staple food,meat dishes,vegetables and vegetarian diet in the hypertriglyceridemia prevalence of the difference were statistically significant?P=0.002?.Greasy diet?P<0.001,P=0.003?and the salty diet?P=0.005,P=0.001?were significantly different in the presence of hypertriglyceridemia and low high-density lipoprotein cholesterolemia.Multivariate analysis showed that smoking status?OR=1.72,95%CI:1.13,2.62,P=0.011?,fatty liver?OR=3.51,95%CI:2.28,5.41,P<0.001?,diabetes mellitus?OR=1.89,95%CI:1.11,3.22,P=0.019?weresignificantlyassociatedwith hyperglycemia.This study show that gender?OR=1.68,95%CI:1.05,2.70,P=0.032?,saltydiet?OR=0.63,95%CI:0.41,0.97,P=0.036?,fattyliver?OR=2.01,95%CI:1.25,3.23,P=0.004?were significantly associated with hypertriglyceridemia.Thegender?OR=0.30,95%CI:0.16,0.55,P<0.001?,fattyliver?OR=2.65,95%CI:1.58,4.43,P<0.001?anddyslipidemiafamilyhistory?OR=3.78,95%CI:1.55,9.23,P=0.004?were significantly associated with low high-density lipoprotein cholesterolemia.The smoking status?OR=1.80,95%CI:1.01,3.21,P=0.048?and fatty liver?OR=2.54,95%CI:1.53,4.22,P<0.001?were significantly associated with high low-density lipoprotein cholesterolemia.The gender?OR=0.63,95%CI:0.42,0.93,P=0.021?,fatty liver?OR=3.01,95CI:2.04,4.44,P<0.001?,dyslipidemia family history?OR=2.52,95%CI:1.12,5.63,P=0.025?were significantly associated with dyslipidemia.The regression model had a good predictive ROC curve area of 0.73,0.71 and 0.72,with good predictive accuracy for hyperglycemia,low HDL-C hyperlipidemia and dyslipidemia.ConclusionHigh prevalence of dyslipidemia in the Hefei population,which main types were low high-density lipoprotein cholesterolemia and hypertriglyceridemia.There are different influencing factors in not the same as types of dyslipidemia.High salt diet,smoking status,dyslipidemia family history,diabetes,fatty liver were risk factor for dyslipidemia.