| Objective The clinical data of patients with endometrial carcinoma in this study through the collection of Qigihar City three hospitals during 2007-2016 hospital treatment,summarize the endometrioid adenocarcinoma region of uterine disease and the basic situation,the non endometrioid adenocarcinoma patient information,the data were summarized and analyzed,the distribution of key factors in endometrioid adenocarcinoma and non endometrioid adenocarcinoma,and provide reference for clinical prevention and treatment of the disease in the region.Method In Qigihar,a three level of first-class hospital hospital treatment during the period of 2007-2016 in 202 cases of endometrial cancer patients with clinical data were retrospectively analyzed,the basic situation of all patients were collected(demographic characteristics,smoking,drinking,menstrual history,pregnancy history,family history,menopause history,physical examination,laboratory examination and related illness)information(visit,auxiliary examination,transfer mode,pathological type,histological grade,immunohistochemical examination and pathological staging)analysis.Using Epidata 3 software to establish database,using SPSS 20 statistical software for data processing and analysis.Result1.The 202 patients included,178 patients were endometrioid adenocarcinoma(88.1%),and 24 patients were non endometrioid carcinomas(11.9%).2.There was no significant difference in demographic characteristics between endometrioid adenocarcinoma and non endometrioid adenocarcinoma.But for smoking and drinking,smoking(P=0.004)and drinking(P<0.001)with significant difference in distribution,the detection rate of non endometrioid adenocarcinoma patients 37.5% smoking rate and drinking rate of 45.8% was higher than that in endometrial carcinoma were 12.4% and 9%.3.Patients in pregnancy(P=0.001)and the age of menarche(P<0.001)have significant differences in the distribution of the non endometrioid adenocarcinoma patients,times of pregnancy over 3 of the positive rate of 58.3% and less than 12 years of age at menarche rate of 95.8% were higher than the detection rate of endometrial adenocarcinoma were 21.9% and 33.7%.4.Patients with a history of cancer in first-degree relatives(P=0.007)have significant differences in the distribution of the first-degree relatives;non endometrioid adenocarcinoma in patients with a history of cancer was higher than that in endometrial carcinoma patients with a ratio of 24.2%.5.Patients for blood routine in patients in normal hemoglobin(P=0.037)and four items of blood coagulation in prothrombin time(P=0.034),thrombin time is normal(P=0.013)have significant differences in the distribution of.The rate of abnormal hemoglobin was 25%,the abnormal rate of prothrombin time was 91.7%and the abnormal rate of thrombin time was 12.5%,which was higher than that of patients with endometrioid adenocarcinoma,9.6%,71.3% and 1.1% respectively.6.For the auxiliary examination for patients in the uterine cavity ultrasonography is normal(P=0.023),curettage cervical involvement(P<0.001),MRI of cervical involvement(P<0.001)and cervical tumor marker CA125 to check whether the normal(P=0.038)have significant differences in the distribution of.Non endometrioid adenocarcinoma of uterine cavity ultrasonography in patients with abnormal rate of 62.5%,involving the cervical curettage rate 66.7%,MRI cervical involvement rate of 70.8% and the abnormal rate of CA125 87.5% was higher than that in endometrial cancer patients,the abnormal rate was 38.2% 25.8%,30.3 and 66.7%.7.Patients with vaginal discharge in the treatment of symptoms(P=0.020),whether there is pain and other symptoms(P=0.017)and the symptoms and diagnosis time interval(P=0.012)were statistically significant differences,non endometrioid adenocarcinoma patients than in endometrial cancer patients from the onset of symptoms and diagnosis time interval in the aged the 6 groups in the proportion to be high,respectively 54.2%,29.2%.The difference in metastasis mode(P=0.002)and histological grade(P<0.001)was also statistically significant. 8.Which accounted for 8.3% of the blood and non endometrioid adenocarcinoma in lymph node metastasis metastasis 8.3% way ratio is higher than that of endometrioid adenocarcinoma;non endometrioid adenocarcinoma accounts for low differentiation ratio of 50% is higher than that of 4.5% endometrioid adenocarcinoma.9.For immunohistochemical examination index,the patients of P53(P=0.034),CKL(P=0.010),Vimentin(P=0.017)positive rate differences were statistically significant.The positive rates of P53,CKL and Vimentin in non endometrioid adenocarcinoma were 100%,higher than those in endometrioid adenocarcinoma,and the positive rates were 81.5%,78.7% and 80.9% respectively.10.Patients in different stages of the distribution of the difference was statistically significant(P<0.001),endometrial adenocarcinoma accounted for a higher proportion in I period,Ia period of 71.3% and 12.4% in Ib stage and other stage are all non endometrioid adenocarcinoma had high proportion.11.Chi square results showed that the patients from the onset of symptoms and diagnosis time intervals associated with staging,Spearman rank correlation showed that the time interval from onset of symptoms to diagnosis(month)is positively related to the severity and staging(rs=0.236,P=0.001).Conclusion1.Women may not rule out endometrial cancer even when symptoms such as abdominal pain,vaginal discharge and vaginal bleeding are not present,or when the auxiliary examination index is normal.2.The proportion of lymph node metastasis of non endometrioid adenocarcinoma is higher than that of endometrioid adenocarcinoma,suggesting that non endometrioid adenocarcinoma is more likely to cause severe results.3.The positive rate of immunohistochemical markers P53,CKL and Vimentin in endometrioid adenocarcinoma is higher than that in endometrioid adenocarcinoma,suggesting that non endometrioid adenocarcinoma is more likely to worsen and metastasis.4.Non endometrioid adenocarcinoma is more likely to deteriorate into stage IV,suggesting non endometrioid adenocarcinoma is more severe.5.From the symptoms to the time interval between the diagnosis and endometrial cancer staging is positively related,suggesting that women groups early detection,early diagnosis,early treatment for endometrial cancer prevention and control of importance. |
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