| Objective:To observe the efficacy and safety of Yishen Guwei decoction on chronic urticaria of exterior deficiency syndrome,and to detect changes of the serum levels of total IgE and complement C3 and C4 before treatment,and to understand the effect of Yishen Guwei Decoction on immune-related indicators of this type of patient,and to explore the mechanism of prescription.Medthods:Using randomized controlled trials,70 patients with chronic urticaria indefinite symptoms were randomly divided into experimental and control groups.The35 patients in the experimental group were treated with Yishen Guwei Decoction orally;35 patients in the control group were treated with oral loratadine tablets and tranilast capsules.Two groups of patients were treated with 4 weeks as a course of treatment,a total of 2 courses were treated to observe the efficacy,recurrence,adverse reactions and changes in serum total IgE,complement C3,C4 levels before and after treat-m ent.Results:1.Of the 70 patients tested,2 were detached from the experimental group and 3 w ere absent from the control group.A total of 65 effective cases were collected.The baseline data of gender,age,disease duration,disease status,serum total IgE,complement C3 and C4 levels were comparable(P>0.05).2.At the end of the treatment period,the symptom scores of the test group and the control group were significantly lower than before treatment(P<0.05);However,there was no statistically significant difference between the groups(P>0.05).3.At the end of the treatment period,the scores of TCM syndromes were significantly lower in the test group than before the treatment.The difference between the two groups was statistically significant(P<0.05).There was no significant differencebetween the control group and before treatment(P>0.05).The difference between the two groups was statistically significant(P<0.05).The test group was superior to the control group.4.At the end of the treatment period,the skin quality of life index(DLQI)scores were compared.The DLQI scores of the experimental group and the control group were significantly lower than before treatment(P<0.05).There was no significant difference between the two groups(P>0.05).5.At the end of treatment,serum total IgE levels were significantly lower in the test group and control group than before treatment(P<0.05).However,there was no statistically significant difference between the groups(P>0.05).The level of serum complement C3 was significantly higher in the test group than before the treatment,and there was a statistically significant difference before and after treatment(P<0.05).There was no significant difference between the control group and the pretreatment group(P>0.05).The difference was statistically significant(P<0.05),and the test group was significantly better than the control group.There was no significant difference in serum c omplement C4 level between the experimental group and the control group before and after treatment(P>0.05).6.In the treatment of 4 weeks,the test group had a markedly effective rate of 33.33% and a total effective rate of 84.85%.The control group had a markedly effective rate of 37.50% and a total effective rate of 81.25%.In the treatment of 8weeks,the test group showed a significant rate of 54.55% and the total effective rate was 87.88%,the obvious rate of the control group was 46.88% and the total effective rate was 84.38%.After 4 weeks and 8 weeks of treatment,there was no significant difference between the test group's dominance rate and total effective rate compared with the control group(P > 0.05).7.The incidence of adverse reactions in the trial group was 3.03%;the incidence of adverse reactions in the control group was 25%,and the incidence of adverse reactions in the trial group was significantly lower than that in the control group(P<0.05).8.After 3 months of followup after treatment,the recurrence rate of the experimental group was 11.11%;the recurrence rate of the control group was 53.33%,and the recurrence rate of the experimental group was significantly lower than that of the conttrol group(P<0.05).Conclusion:The clinical curative effect of Yishen Guwei Decoction in treating chronic urticaria manifest deficiency syndrome is definite,and the incidence of adverse reactions is low;In controlling the recurrence of the disease,there is a clear advantage compared with the treatment of loratadine tablets combined with tranilast capsules. |
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