The Changes And Clinical Value Of Serumal Soluble Suppssion Of Tumorigenicity-2 And Procalcitonin In AECOPD

Objective: To analyse the severity of disease and the clinical value of serumal soluble suppssion of tumorigenicity-2 and procalcitonin in the patients with acute exacerbation of chronic obstructive pulmonary disease(AE COPD).Methods: We detect the serumal contents of the soluble suppssion of tumorigenicity-2,procalcitonin,C reactive protein in 30 healthy control group and 120 AECOPD patients in hospital before and after the treatment,and researching its correlation with severity of COPD,COPD assessment test(CAT)and 6 minutes walk distance(6MWD).Results: Comparing the patients after the treatment and the healthy control group,serumal contents of the soluble suppssion of tumorigenicity-2,procalcitonin,C-reactive protein were obviously elevated in AECOPD patients before the treatment(p<0.05).To some extent,the contents of these indiacators were increasing with the aggravation in the severity of COPD.The severity classification of COPD were positively correlated with serum al contents of sST2,CRP and PCT(r = 0.58 8,r =0.447,r =0.3 05,p <0.01),and the serumal contents of sST2 and PCT in the combined class ? and class ? AECOPD patients were significantl y lower than the combined class ? and class ? AECOPD patients(p<0.05).The serumal sST2 was positively correlated with CAT(r=0.363,p<0.01),and was negatively correlated with 6 MWD(r=-0.434,p<0.01).Conclusions: The serumal contents of sST2 and PCT in AECOPD patients of class ? and class ? were higher than class ? and class ? AECOPDpatients,and with the condition improved,serumal contents of sST2 and PCT decreased significantly.Serumal sST2 and PCT can reflect the severit y of AECOPD patients in some extent,and also have certain clinical value to evaluate the quality of life in AECOPD patients.