Changes Of D-dimer, C-reactive Protein, Procalcitonin With AECOPD Patients Who Were Blood Stasis Type And Xuefuzhuyu Decoction Clinical Observation

Objective:To observe Changes of D-dime、C-reactive protein、Procalcitonin with Acute Exacerbation of Chronic Obstructive Pulmonary Disease patients who were blood stasis type;through observing the characteristics of Xuefuzhuyu Decoction intervention, then evaluate the clinical therapeutic effect of Xuefuzhuyu Decoction.Methods:According to inclusion criterions,60AECOPD blood stasis patients from February2011to February2012in our hospital were divided randomly into two groups,30cases as treated group,which were treated with Xuefuzhuyu Decoction and conventional therapy of western medicine.The other cases as controlled group,which were treated without Chinese Medicine.According to Traditional Chinese Medicine(TCM) dialectic criterions,all cases were blood stasis type.All patients were given conventional therapy of western medicinesuch as controllable oxygen treatment,anti-infection,spasmolysis,dissipating phlegm and antasthmatic,and treated group was added Xuefuzhuyu Decoction.treat10days. On the first day and the11th day,all patients have to do the evaluation of clinical symptoms,signs and pulmonary fuction,and detect the level of Blood gas analysis,D-dimer,C-reactive protein,Procalcitonin,all the data are used statistical software SPSS17.0statistical analysis.Results:1.Before treatment, D-dimer has negative correlation with FEV1%,Artery blood oxygen partial pressure(P<0.05), D-dimer has positive correlation with Carbon dioxide points pressure(P<0.05); C-reactive protein has negative correlation with FEV1%(P<0.05), has negative correlation with Artery blood oxygen partial pressure(P<0.01), has positive correlation with Carbon dioxide points pressure(P<0.05); Procalcitonin has negative correlation with FEV1%,Artery blood oxygen partial pressure(P<0.05), has positive correlation with Carbon dioxide points pressure(P<0.05).The leveles of FEV1%, Artery blood oxygen partial pressure higher than before treatment,The leveles of D-dimer, C-reactive protein, Procalcitonin before treatment higher than the after(P<0.01). 2.After treatment, D-dimer of treatment group decreased significantly(P<0.05),the control group has declined,but with no statistical significance(P>0.05); Procalcitonin of two groups drops,the treatment group was more obvious(P<0.05); C-reactive protein of two groups decreased significantly,but there was no statistics difference between the two groups.3.Level of FEV1%higher than before in two grouos(P<0.01), treatmen group is better than control group.Level of FEV1/FVC higher than before, however,these results did not reach statistical significant between two groups (P>0.05); PO2of two groups has increased,the treatment group improved degree is more obvious(P<0.05), PCO2of two groups decreased,but no statistical difference (P>0.05)4.The effect of treatment group is better than the control group. Caugh, phlegm, asthma, the tongue,lip claw vioet dark,pulse are easer than before (P<0.05),but lungs detect rales of has nothing statistics difference between two groups (P>0.05)5.Two groups of the healing process does not appear serious adverse reactions.Conclusion:1.D-dimer,C-reactive protein,Procalcitonin in Acute period higher than stable,they have correlation with the severity of AECOPD,they can be as the evaluation indicator of AECOPD.2.Effectiveness of treatment group were better than control group.Effect of Xuefuzhuyu Decotion can improve the tongue,lip claw vioet dark,pulse and blood stasis symptoms. The decotion can lower the level of D-dimer,Procalcitonin with these patients, The decotion can improve high agglutination condition to blood stasis type AECOPD patients,has obvious certain anti-inflammatory effects.3. Xuefuzhuyu Decotion in treating blood stasis type AECOPD patients can relieve cough,sputum,asthma,improve FEV1%and PCO2, improve lung function and oxygenation function.4.Xuefuzhuyu Decotion in treating blood stasis type AECOPD worthy of clinical application.