| Objective:Based on the evidence-based medicine,the systematic evaluation of Tibetan and Han blood lipid levels and different altitude of the two ethnic groups of lipid levels,so asto better guide the residents of a reasonable lifestyle,eating habits,reasonable exercise,so that the body of blood lipids Level to achieve steady-state balance.Methods : Computer search Pub Med,CNKI,VIP,Wan Fang Data,CALIS Qinghai and China Information Center and other Chinese and English database,collected the RCT study of compared the Tibetan and Han blood lipid levels,the time limit for the search database from the beginning of the establishment of their respective databases as of 2016 October.At the same time,all the references included in the study were collected and read and recorded the meeting on the comparison of blood lipid levels of Tibetan and Han nationality,and the comprehensive information was collected.After the researchers in accordance with the formulation of the inclusion and exclusion criteria to select the literature to determine whether the inclusion of the study,the final inclusion of the document with their own data extraction table to fill out the relevant indicators,the application of Rev Man 5.3 software for the meta-analysis,comparison of Tibetan,Metabolic status and different levels of altitude under the two lipid metabolism.Results:A total of 22 randomized controlled trials(RCT)were included in the data of the meta-analysis,included 22,673 individuals,Among them,there were 12536 Han and 10137 Tibetan.The outcome indexes were blood lipids,namely total cholesterol(TCH),triglyceride(TG),High density lipoprotein(HDL-C),low density lipoprotein(LDL-C).At the same time,22 articles,high altitude(3500-5500 m above sea level)7,a total of 4495 people,including the Han nationality has 1726 people,Tibetan 2769 people;high altitude(elevation 1500-3500m)11,a total of 13486 individuals,There are8084 Han people,Tibetan 5402 people;low elevation(elevation <1500m)2,a total of 1402 people,of which there are 1202 Han,Tibetan 200 people.Therefore,this article will be divided into four groups according to the blood lipids,and according to different altitude classification criteria divided into three subunits,respectively Meta analysis,subgroup analysis,sensitivity analysis and publication bias,the results are as follows:1 Comparison of Tibetan,Han TCH1.1TCH meta-analysis results: SMD=0.18,95% CI [0.08,0.28],P=0.0006,the difference was statistically significant.1.2TCH subgroup analysis results:(1)ultra-high altitude: SMD=0.31,95% CI [0.16,0.46],P<0.0001,the difference was statistically significant.(2)high altitude: SMD=0.08,95% CI [-0.09,0.25],P=0.35,the difference was not statistically significant.(3)low altitude: SMD=-0.57,95% CI [-1.99,0.86],P=0.44,the difference was not statistically significant.2 Comparison of Tibetan,Han TG2.1TG meta-analysis results: SMD=-0.04,95% CI [-0.20,0.12],P=0.61,the difference was not statistically significant.2.2TG subgroup analysis results:(1)ultra-high altitude: SMD=0.01,95% CI [-0.20,0.22],P=0.92,the difference was not statistically significant.(2)high altitude: SMD=-0.10,95% CI [-0.22,0.02],P=0.09,the difference was not statistically significant.(3)low altitude: SMD=-0.06,95% CI [-0.21,0.10],P=0.46,the difference was not statistically significant.3 Comparison of Tibetan,Han HDL-C3.1HDL-C meta-analysis results: SMD=-0.08,95% CI [-0.20,0.04],P=0.20,the difference was not statistically significant.3.2HDL-C subgroup analysis results:(1)ultra-high altitude: SMD=0.03,95% CI [-0.19,0.25],P=0.79,the difference was not statistically significant.(2)high altitude: SMD=-0.09,95% CI [-0.28,0.09],P=0.32,the difference was not statistically significant.(3)low altitude: SMD=-0.03,95% CI [-0.44,0.37],P=0.88,the difference was not statistically significant.4.Comparison of Tibetan,Han LDL-C4.1LDL-C meta-analysis results: SMD=0.35,95% CI [0.18,0.51],P<0.0001,the difference was statistically significant.4.2LDL-C subgroup analysis results:(1)ultra-high altitude: SMD=0.55,95% CI [0.25,0.85],P=0.0003,the difference was statistically significant.(2)high altitude: SMD=0.11,95% CI [-0.24,0.47],P=0.54,the difference was not statistically significant.(3)low altitude: SMD=-0.61,95% CI [-1.85,0.64],P=0.34,the difference was not statistically significant.To sum up:1.The average TCH and LDL-C levels of Tibetan are higher than those of Han nationality.2.There was no difference between the average TG and HDL-C levels of Tibetan and Han nationality.3.The average TCH and LDL-C levels of Tibetan are higher than those of Han nationality in ultra-high altitude areas.4.There was no difference between the average TG and HDL-C levels of Tibetan and Han nationality in ultra-high altitude areas.5.There was no difference in the average TCH,TG,HDL-C and LDL-C levels between Tibetan and Han nationality in high altitude areas.6.There was no difference in the average TCH,TG,HDL-C and LDL-C levels between Tibetan and Han nationality in low altitude areas.Conclusion:1.The meta-analysis showed that there were differences in lipid metabolism between Tibetan and Han,and the lipid metabolism of the two ethnic groups at different altitudes had their own characteristics.2.In TCH,LDL-C,HDL-C: Compared with the Han,the Tibetan has a tendency to develop Hypercholesterolemia,Higher low density lipoproteinemia,Lower high density lipoproteinemia.3.In TG : Compared with the Tibetan,the Han has a tendency to develop Hypertriglyceridemia.4.With the elevation of altitude,the above conclusions tend to be more obvious,may be with the ultra-high altitude residents of the lifestyle and eating habits are related. |
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