Analysis Of Irregular Antibody Results In Pregnant Women From Five Ethnic Groups In Qinghai

Objective To detect and analyze of irregular antibodies in five ethnic groups of Han,Tibetan,Hui,Tu and Salar in Qinghai Province in order to find clinically meaningful irregular antibodies,and preliminarily probe the distribution characteristic of irregular antibodies in the five nationalities.Methods A total of 11991 pregnant women from Han,Tibetan,Hui,Tu and Salar ethnic groups in Qinghai Red Cross Hospital from Jan 1st,2014 to Jan 1st,2017 were used to screen and identify the irregular antibodies to summarize and analyze the positive detection rate and theirs specific type distribution.Results(1)The positive rate of irregular antibodies in five ethnic groups in Qinghai was as follows:Salar pregnant women(1.89%),Hui pregnant women(1.05%),Tu pregnant women(0.50%),Tibetan pregnant women(0.39%),Han pregnant women(0.35%).The positive rates of irregular antibodies between five ethnic groups were compared:The positive detection rate of irregular antibodies among Han pregnant women was 0.35% and 1.05% among Hui pregnant women,showing a statistical difference(P<0.05).The positive detection rate of irregular antibodies among Han pregnant women was 0.35% and 1.89% among Salar pregnant women,showing a statistical difference(P<0.05).The positive detection rate of irregular antibodies among Tibetan pregnant women was 0.39% and 1.05% among Hui pregnant women,showing a statistical difference(P<0.05).The positive detection rate of irregular antibodies among Tibetan pregnant women was 0.39% and 1.89% among Salar pregnant women,showing a statistical difference(P<0.05).There was no significant difference in the positive rate of irregular antibodies between the other ethnic groups.(2)There were differences in the frequency and distribution of irregular antibodies in five ethnic groups.(3)There were 63 positive cases of irregular antibodies in five national pregnant women.Among them,there were 54 cases of RH blood group system,anti-D(19 cases)was the most common,anti-E(14cases)was the second,anti-c E(9cases),anti-c(7cases)and anti-M(4cases)were also more common detected,anti-e,anti-CD,anti-Lea,anti-P1 and cold antibody were also found.Irregular antibodies were mainly composed of type of Ig G antibody.The positive detection(4)rate of pregnant women of Han,Tibetan,Hui with no less than two times of pregnancies was higher than that of pregnant women with 1st pregnancy,showing a statistical difference(P<0.05).While there was no significant difference between the positive detection rate of pregnant women of Tu,Salar with no less than two times of pregnancies and that of pregnant women with 1st pregnancy(P>0.05).Conclusion(1)There may exist national discrepancy in the distribution of irregular antibodies of the pregnant women of ethnic groups of Han,Tibetan,Hui,Tu and Salar in Qinghai Province.(2)Clinically,it is need to add the detection of Rh E,Rhc E,Rhc and other clinical common irregular antibodies,excepting the routine identification of ABO blood group and Rh D,in order to avoid the occurrence of HTR and HDN.