Studies On The Chemical Constituents Of Horsfieldia Glabra

The dissertation mainly reported chemical constituents of one medicinal plant Horsfieldia glabra.Totally 51 compounds were isolated from this plant,including 7 new compounds.By means of various chromatography methods and spectroscopic evidences,51 compounds were isolated and identified from the trunk and leaves of Horsfieldia glabra.The type of structure are including: 1,3-diarylpropanes,sesquiterpenes,diterpenes,triterpenes,flavans,chalcones,flavanones,flavonoid glycosides,dihydroflavones,arylalkanones,simple aromatic compounds,steroids and ligans.There are(2R,4R)-4?-hydroxy-3?,5?-methyl-6,7-methylenedioxy-4-O-2?-cycloflavan(1),(2R,4R)-4?-hydroxy-3?-methyl-6,7-methylenedioxy-4-O-2?-cycloflavan(2),(-)-catechin(3),(-)-epicatechin(4),(-)-festidinol(5),naringenin(6),(-)-butin(7),(-)-eriodictyol(8),liquiritigenin(9),quercetin(10),morin(11),sulfuretin(12),4,2?-dihydroxy-4?-methoxychalcone(13),(3R)-vestitone(14),quercetin-3-O-?-D-glucoside(15),morin-3-O-?-rhamnopyranoside(16),kaempferol-3-O-?-L-rhamnopyranoside(17),quercetin-3-O-?-L-rhamnopyranoside(18),hemipholin [(+)-6-C-?-D-glucopyranosyl(2S)naringenin](19),1-(2?,4?-dihydroxyphenyl)-3-(2??-hydroxy-4??,5??-methylenedioxyphenyl)-propane(20),1-(2?-hydroxy-4??,5??-methoxylphenyl)-3-(3??,4??-methylenedioxyphenyl)-propane(21),1-(2?,4?-dihydroxy-3?-methylphenyl)-3-(2??-hydroxy-4??,5??-methylenedioxyphenyl)-propane(22),virolane(23),1-(4?-hydroxy-2?-methoxyphenyl)-3-(4??-hydroxy-3??-methoxyphenyl)-propane(24),1-(2?,4?-dihydroxyphenyl)-3-(3??,4??-methylenedioxyphenyl)-propane(25),1-(2?,4?-hydroxy-3?,5?-dimethylphenyl)-3-(2??-hydroxy-4??,5??-methylenedioxyphenyl)-propane(26),1-(2?,4?-dihydroxyphenyl)-3-(2??-methoxy-4??,5??-methylenedioxyphenyl)-propane(27),bauhiniasin(28),euonyphenylpropane A(29),horsfiebra A(30),horsfiebra B(31),myristinin G(32),myristicyclin A(33),betulinic acid(34),(-)-(3R)-18-hydroxygeranyllinalool(35),plaunotol(36),4(14)-eudesmene-6?,11-diol(37),(-)-clovane-2,9-diol(38),(-)-caryolane-1,9?-diol(39),vomifoliol(40),(-)-sesamin(41),(-)-kobusin(42),(+)-piperitol(43),(-)-eudesmin(44),demethylpiperitol(45),isocubebin(46),dodecanoylphloroglucinol(47),1-(2,6-dihydroxyphenyl)-4-methyl-4-tridecen-1-one(48),3,6-dihydroxy-2-[1-oxo-9(Z)-octadecenyl]-cyclohex-2-en-1-one(49),3,4-dihydroxybenzoic acid(50),?-sitosterol(51).Compounds 1-2,20,30-32,35 are novel,and compounds 6-8,10-11,14-19,24,26-29,34,36-40,42,44-46 were isolated from the genus Horsfieldia.Except for compound 48,other compounds were separated from Horsfieldia glabra for the first time.Selected compounds 1-2,20,23,31,34-35,42-43,47 were assessed for their in vitro growth inhibitory influences against the different cancer lines(A-549,HL-60,SMMC-7221,SW480 and MCF-7).Compound 31 exhibited certain cytotoxic activitity for five human cancer cells with IC50 values of 18.58 ?M,20.76 ?M,13.92 ?M,18.12 ?M,and 12.92 ?M,respectively.The other compounds had no activitity in vitro.At last,1,3-diarylpropanes in the plants were reviewed,including chemical constituents and biological activities.