Different Dose Urokinase On Cerebral Hematoma Within Drainage Effect

Objective:To observe different doses(large dose of 50000 u/time,dose of 30000 u/time,small doses of 10000 u/times)urokinase on cerebral hemorrhage minimally invasive insertion of postoperative patients with cerebral hematoma drainage dissolved in effect and the influence of clinical curative effect,statistical analysis,comparative study,to explore suitable dose,so as to guarantee the curative effect,avoid waste,reduce the possible side effects,and makes the corresponding mechanism of clinical phenomenon of speculation.Methods:Choose the brain hematoma minimally invasive tube insertion.We 66 cases of cerebral hemorrhage patients,all patients in the health industry standard of the People's Republic of China: adult diagnostic criteria made spontaneous cerebral hemorrhage(WS320-2010)",and set out standards,to eliminate possible interference to the case.All of the selected patients were between 35 and 50 ml of hematoma,which was between 10 and 14 hours after the onset of the onset of the disease.According to the dosage of unease,the patients were randomly divided into three groups,and group A(22)gave urea 10,000 u + physiological saline solution to the internal drainage tube.The group B(22)gave urea 30,000 u + saline solution to the internal drainage tube.The C group(22 people)gave the urea 5,000 u + physiological saline 5ml to the posterior cerebral drainage tube injection.All three groups of patients were given a catheter after the urease injection,and two hours later they were released,and the urease was injected every eight hours and injected six times.Note the prevention of complications.All patients immediately after the CT inspection,check again after the injection of urokinase 6 times CT,hematoma volume in the field formula,then calculate the hematoma clearance,clearance of hematoma =(before the injection of urokinase of postoperative hematoma volume-injection of urokinase after six hematoma volume)/before the injection of urokinase of postoperative hematoma volume,postoperative routine hemostatic,use of antibiotics,dehydration,protect brain cells,prevention of stress ulcer,nutritional therapy,such as analysis of three groups of patients with injection of urokinase afterbrain 6 times in hematoma clearance,disabling MRS score 14 days after operation,14 days after GCS score and other indicators.Results :In patients with cerebral hemorrhage in the brain hematoma drainage tube after treatment,the application should be urokinase 10000 u,30000 u,50000 u any two groups of brain hematoma clearance and disabling MRS score 14 days postoperatively,GCS score 14 days after comparison difference is not obvious(P > 0.05),no statistical difference.Conclusion :In patients with cerebral hemorrhage brain hematoma catheter drainage treatment,application of urokinase can promote the dissolution of hematoma,reduce the toxicity of hematoma and the effect of the placeholder.Application of urokinase 10000 u,30000 u,50000 u these three different doses of clinical effect,from the brain hematoma clearance and disabling MRS score 14 days postoperatively,GCS score 14 days after this a few indicators,data contrast difference is not obvious,no statistical significance.In this study,different dose urokinase in this test the brain hematoma drainage effect has no obvious difference,small dose of urokinase curative effect is not seen is reduced,is worth popularizing in clinical application.