The Prognostic Value Of Preoperative Neutrophil-lymphocyte Ratio In Patients With Bladder Carcinoma

Objective: Amounts of studies indicate inflammatory response factors are closely correlated to oncological prognosis.However,the value of inflammatory factors in prognosis of bladder carcinoma(BC)remains controversial recently.We compared the prognostic and clinicopathological relationship between three biomarkers neutrophil-lymphocyte ratio(NLR),lymphocyte-monocyte ratio(LMR),platelet-lymphocyte ratio(PLR)and bladder cancer patients to judge which of these three biomarkers will have a better predictive value in bladder cancer.Methods: We selected data of cases of 113 patients with BC who underwent radical cystectomy(RC)from March 2010 to September 2016 in our hospital.Kaplan-Meier test and Cox multi-factors-regression model are used to statistically analyse the overall survival(OS)and clinicopathological correlation.And SPSS 22.0 software is applied to process all data.Results: High level of NLR is connected with the clinical staging and pathological grading of BC.Meanwhile,low level of LMR is connected with the clinical staging and pathological grading of BC.Besides,univariate-regression model reveals that high level of NLR(? 3.7;HR = 6.899;P = 0.001),low LMR(? 3.1;HR = 3.631;P = 0.002),and high PLR(? 150;HR = 2.041;P = 0.046)all influence OS,the difference is statistically significant.Importantly,multivariate analysis confirmed independent significant correlations among high NLR(HR = 4.232;P = 0.018)and OS in BC.Conclusions: NLR exhibited a significantly higher predictive accuracy compared with the LMR and PLR,in indicating that these factors could be an useful prognostic markers for patients undergoing RC for BC.