Effect Of Chinese Medicine Cycle Therapy On Endometrial Receptivity And VEGF For Patients With Recurrent Implantation Failure

Objective:Give Recurrent implantation failure(RIF)of In-vitro fertilization and embryo transfer(IVF-ET)Patient traditional Chinese medicine(TCM)cycle therapy,passing observation relevant indicators of endometrial receptivity before and after therapy and control group’s,seeing TCM cycle therapy to improve RIF in patients with endometrial receptivity and implantation rate of the curative effect and mechanism,expecting prospective clinical therapeutic proposal.Methods: Frozen thawed embryo transfer patients as the research object,60 cases are interview observation group(RIF patient),and 60 cases are control group(Tubal factor IVF).Given the observation group TCM cycle therapy for 2 menstrual cycles,control group not given the drug intervention,compare the statistical of TCM syndrome score,serum endocrine,endometrial thickness,style and type of blood,and observation Vascular endothelial growth factor(VEGF)in immunohistochemical,Western blot,RT-PCR detection and ABC-ELISA,Statistion of FET implantation rate and clinical pregnancy rate.Results:1.After observation group was treated with 2 cycles of TCM cycle therapy,the TCM syndrome score decreased(P<0.05);compared withthe control group,there was no difference(P>0.05).2.The serum levels of FSH,LH,FSH/LH and E2 in the observation group after treatment were significantly higher than before(P<0.05);compared with those in the control group was no difference(P>0.05).3.After treatment,the expression of VEGF and VEGF mRNA in endometrium and serum were improved(P<0.05);there was no significant difference in control group(P>0.05).4.There was no significant difference between the control group and the observation group after cure on the serum levels of hormone,implantation rate and clinical pregnancy rate after 14 days in FET cycle(P>0.05).Conclusion:Given patience TCM cycle therapy before the FET cycle can improve TCM syndrome score,and impreve the endometrial morphology,and enhanc the expression of serum and endometrial VEGF,and improve endometrial receptivity,so as to improve the clinical pregnancy rate.