| Objective :This reasearch is to study the relationship between lung cancer and age,sex, smoking, area, chronic lung disease, tumor marke and so on.Methods: TO study and analysis the Yanan Hospital of Kunming city from May 2014 to 2016 have confirmed lung cancer which by Pleural effusion or sputum exfoliated cells, bronchial brushing or biopsy, ultrasound or CT guided percutaneous lung biopsy,lymph node biopsy, thoracic surgery and pathology and cytology.Results: 1. In all 260 cases there is squamous cell carcinoma 106 cases (accounting for 40.8%), adenocarcinoma 104 cases (accounting for 40%), small cell carcinoma 27 cases (accounting for 10.4%), squamous cell carcinoma 13 cases (accounting for 5%), and other types of cancer 10 cases (accounting for 3.8%). Squamous cell carcinoma and adenocarcinoma accounted for the highest proportion, followed by small cell carcinoma, adenocarcinoma. 2?Among 260 cases, the total number of males was 200 (accounting for 76.9%), while the total number of females was 60(23.1%).So the male sex is one of the risk factors for lung cancer. The majority of male patients with squamous cell carcinoma, a total of 99 people , accounting for 49.5% of all male patients, meanwhile women with adenocarcinoma up to a total of 43 people,accounting for about 71.7% of all female patients. The relationship between lung cancer pathological type and sex (P<0.001), the difference was statistically significant. 3?The mean age of the 260 patients was 62.4 years, and the number of women (age = 58.7) was lower than that of men (age 63.6). The highest incidence rate of male was 60 to 69 years old, accounting for 43.8%, by contrast the highest incidence rate of women was from the age of 50 to 59, accounting for 30.3%.The highest incidence of lung cancer in the age group is 41 to 64. The incidence of lung cancer and age (P=0.007), the difference was statistically significant. 4?In which 260 cases there is 169 smokers, accounting for 65%, the smoking index greater than or equal to 400 to 86 people,accounting for 51% of the number of all smoking. The highest proportion of squamous cell carcinoma and small cell carcinoma in smokers,which respectively accounted for 46.2% and 40.7%, followed by adenosquamous carcinoma accounted for (30.8%). In contrast,the lowest incidence of smoking in patients with adenocarcinoma. The relationship between smoking and pathological types of lung cancer (P=0.003),there is statistically significant. 5?In 260 cases previous with chronic lung disease have 35 cases, of which 28 cases is chronic obstructive pulmonary disease (COPD), 6 cases is pulmonary tuberculosis, 1 cases is pneumoconiosis. In this research cases had a total of 8 cases in the past have had exposure. 6?In all 260 cases a total of 28 cases of lung cancer patients who lived in Yunnan Qujing,which is considered to be a high incidence of lung cancer. And there is a total of 13 cases in Chuxiong. Among them, 77% of lung cancer patients in Chuxiong were squamous cell carcinoma,While 80% of lung cancer in Honghe region was adenocarcinom. The regional difference with the proportion of lung cancer and pathological type (P<0.001), the difference has statistically significant. 7?In 260 cases,tumor markers were detected in 155 cases,Of which there is 91 patients with one or more different degrees of increase. In all adenocarcinoma and small cell carcinoma cases AFP were negative. The adenosquamous carcinoma had the highest positive rates of CA125 and CA199 which acounted 75% and 38%. Secondly, is squamous cell carcinoma, the positive rates of CA125 and CA199 was 40% and 15% respectively. The CA199 of all the small cell carcinomas were negative. The positive rate of CEA in patients adenocarcinoma,squamous cell carcinoma and adenosquamous carcinoma was 22%,3 5% and 38% in sequence.Conclusion: Lung cancer is a disease caused by many factors, male, age, smoking are risk factors for lung cancer; Previous had chronic pulmonary lung disease, occupation exposure and severity environmental pollution in different regions has increased the risk of lung cancer in a certain extent;The lung cancer pathological there are differences between different sex; With the increasingly serious environmental pollution, the age of onset of lung cancer is younger; Combined with the detection of multiple tumor markers have significance in the early diagnosis of lung cancer;Therefore, it is necessary to actively advocate the promotion of smoking cessation,improve the feasibility of regular physical examination of patients with high risk of lung cancer, improve the diagnosis rate of histopathology, Which can make we do early prevention,early detection and early treatment to improve the prognosis of lung cancer. |
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