Evaluation Of Reliability And Validity And Application Research Of Chinese Version Of MMAS-8 In Patients With T2DM

Objectives:This study aims translation English version of MMAS-8 into Chinese and evaluates the reliability and validity of it in patients with type 2 diabetes.Moreover,to explore the influence of different factors on the patients medication complication and provides the theoretical basis for diabetes treatment and education.Methods:We translate English version of MMAS-8 into Chinese and use the Chinese version of MMAS-8 and MMAS-4 to survey 148 type 2 diabetes patients who were treated in the first affiliated hospital of kunming medical university.We collect the patient's demographic and clinical date,such as gender,age,course,professional,the type of health care,education,height,weight,duration,complications,treatment plan and HbAlc.About 20%patients are randomly selected to finish retest of the Chinese version of MMAS-8 through call visits 2 weeks later.We use the IBM SPSS 23(2)software to investigate the reliability and validity of the scale and explore the influence of different factors on medication adherence.Results:(1)We completed the translation of Chinese version of MMAS-8 and applied to 148 patients with type 2 diabetes(male 69,female 79),within 30 patients completed the test-retest portion.(2)The score of MMAS-8 of 148 patients with type 2 diabetes was 6.31± 1.88,and the low,medium and high adherence groups were 42(28.38%),56(37.84%)and 50(33.78%).(3)The reliability test of Chinese version of MMAS-8 showed that Cronbach's alpha test was 0.776,the ICC was 0.854(P<0.05).The construct validity test showed that:the factor analysis extracted three common factors,which explained 67.28%of the total variance,each item in the main factor of factor load were more than 0.5.The convergent validity test:the correlation coefficient between Chinese version of MMAS-8 and MMAS-4 was 0.878(P<0.001).The discrimination validity:Chinese version of MMAS-8 scores of good glycemic control group(HbA1c<7%)was higher than poor glycemic control group(HbA1c?7%)[(7.20±1.039)&(5.94±2.027),Z=-3.849,P=0.00],which the difference had statistically significant.Comparing two groups in different compliance distribution had statistical significance(?2?14.554,P=0.01).(4)Single factor and multiple factors analysis were applied of the relationship between influencing factors and medication adherence.The single factor orderly classification logistic regression analysis showed that gender(wald?2=7.046,P=0.008),hypoglycemic therapy(wald?1=6.158,P=0.013)had statistically significance influence on medication adherence.The multiple factors orderly classification of logistic regression analysis showed that gender,healthy care,hypoglycemic therapy had statistical significance influence on medication adherence.Men compared to women[OR=0.405,95%CI(0.197,0.829)],medical insurance for urban workers compared to self-paying[OR=0.130,95%CI(0.021,0.800)]and monotheraphy compared to multi-drug treatment[OR=2.970,95%CI(1.499,5.882)]were poor on medication adherence.Conclusions:(1)The Chinese version of MMAS-8 with good reliability and validity.(2)Chinese version of MMAS-8 can be applied for patients with type 2 diabetes,applied for evaluating the patient's medication adherence and guide the clinical work.(3)The medication compliance of type 2 diabetes was poor relatively.(4)The medication adherence of type 2 diabetes was connected with gender,the type of medical insurance and the complexity of the hypoglycemic therapy.