An Analysis On The Poliomyelitis And Measles Antibody Levels And The Influencing Factors Among The Childern Aged 0-6 Years In The Urban Areas Of Liuzhou City

ObjectiveTo understand the levels of poliomyelitis antibody among healthy children aged 0 month-6 years and measles antibody levels in the population of urban Liuzhou,investigate the effect of different immunization programmes for poliomyelitis vaccine and the persistence of poliomyelitis vaccine-induce immune responses,analyze influencing factors of positive measles and poliomyelitis antibody,evaluate the effects of immunization planning and provide scientific basis for immunization program in the urban areas of Liuzhou city.MethodsDescriptive epidemiological method was used to analyze the distribution characteristics of poliomyelitis and measles antibody in 3727 children aged 0-6years in the urban areas of Liuzhou.Demographic information,immunizaiton history and blood samples were collected from the children in the 5 districts of Liuzhou city from March to July in 2016.Enzyme linked immunosorbent assay(ELISA)was used to detect anti-poliomyelitis IgG and anti-meales IgG in theblood samples.Chi-square test,Cochran-Armitage trend test and multivariate logistics regression analysis were used to compare the levels of poliomyelitis and measles antibody and influencing factors in the children with different characteristics.Results1.The total positive rate of poliomyelitis antibody was 90.4%(3369/3727).There was no statistically significant difference in the positive rate of poliomyelitis antibody between different gender(?~2=0.160,P=0.689),nation(?~2=3.070,P=0.215)and vaccine category(?~2=5.941,P=0.051).Statistically significant differences were found in the positive rate of poliomyelitis antibody between different education levels of the children's mothers(?~2=11.652,P=0.003),demographic characteristics(?~2=21.887,P < 0.001)and immunization doses(?~2=10.382,P=0.001).Multivariate analysis showed that the education levels of the mothers,demographic characteristics and the intervals after vaccination were the factors influencing the antibodies in the population of Liuzhou urban area.The positive rate of poliomyelitis antibody declined with increasing vaccination intervals for the children in the groups with 3-dose OPV(Z=4.533,P<0.001)and 4-dose IPV(Z=2.537,P=0.006).2.The total positive rate of measles antibody was 99%(3691/3727).There was no statistically significant difference in the positive rate of meales antibody between different gender(?~2=0.045,P=0.832),nation(?~2=0.367,P=0.832)and the mothers' education levels(?~2=0.281,P=0.869).Statistically significant differences were found in the positive rate of meales antibody between different districts(?~2=12.018,P=0.017),age groups(?~2=16.230,P<0.001),demographic characteristics(?~2=8.251,P=0.004)and immunization doses(?~2=69.610,P< 0.001),Multivariate analysis showed that the immunization doses andvaccination intervals were the factors influencing the antibodies in the population in urban Liuzhou.Conclusions1.An outbreak of polio and meales epidemics are less likely to happen in the near future,because a relatively high level of the positive rates of polio and measles antibody in the children aged 0-6 years in the Liuzhou urban areas were maintained,meeting the requirements of the immune barrier.2.The timely supplementary immunization of polio vaccine and measles revaccination are very scientific and necessary.3.Immunization plan in urban Liuzhou is standadised,while emphasis should be put on strengthening the supervision for the floating children and the children in susceptible ages,enlarging publicity for the children's mother especially those who were less-educated and improving the supervision and training for the immune outpatients of Liunan District.