Therapeutic Evaluation Of The Tiaogan Jiangya Prescription For The Hypertensive Patients In The Community:Ambulatory Blood Pressure Monitoring Evaluation

Objective:Combining with TCM theory,apply 24 h Ambulatory Blood Pressure Monitoring(ABPM)to observing the effects on blood pressure of patients who suffered Ganhuo Kangsheng type hypertention and took Tiaogan Jiangya prescription within the community in order to evaluate the clinical effect of the prescription.Methods:Adopting multi-center study,input in patients with 1or 2 stage isolated systolic hypertension who were 45 to 79 years old.Based on the inclusion criteria,eligible patients were selected to participate in randomized grouping in order to conduct a randomized,double-blind study.According to the screening period,the treatment period and the follow-up period,carried out the treatment and filled in the cases.The experimental group was treated with the combination of non-drug therapy,combined antihypertensive therapy and the treatment of the Tiaogan Jiangya prescription fine granules while the control group was treated with the combination of non-drug therapy,combined antihypertensive therapy and the treatment of the placebo which was the same specification of the Tiaogan Jiangya prescription fine granules.All subjects wore 24 h ABPM at baseline 0 week,12 weeks after treatment,24 weeks after treatment and filled in the relevant scales.Unblind work and statistical analysis were conducted when the test was over,all results were recorded in CRF.Established EXCEL database based on the quality of life scale and analyzed date with the help of the FAS analysis,PPS analysis,SS analysis and SPSS 17.0.Observe the effects of the Tiaogan Jiangya prescription on ambulatory blood pressure level,systolic blood pressure(SBP)and the changes of diastolic blood pressure(DBP)and the changes of pulse pressure(PP),the change of 24 hours ambulatory blood pressure load analysis.Results:Baseline data were comparable between the two groups before treatment.In 12 week and 24 week,systolic blood pressure,pulse pressure and blood pressure load were decreased in the experimental group and the control group,and there was no significant difference between the two groups(p>0.05).In 12 week,there was significant difference between the control group and the experimental group in the 24 hour systolic pressure load group(p< 0.05).Conclusion:This study shows that Tiaoganjiangya prescription combined with losartan compared with losartan alone could reduce the systolic blood pressure,pulse pressure,blood pressure down load and change of circadian rhythm of blood pressure.However,Tiaogan Jiangya prescription group had no obvious advantage,the control group and the experimental group had no significant difference in curative effect evaluation,which was namely negative effect.