Study On Medication Regularity Of Peri-menopausal Insomnia In Traditional Chinese Medicine

Object: To explore the use rule of Chinese herbs in the treatment of peri-menopausal insomnia,including frequency of drugs,four properties and five tastes,drugs to meridian,high frequency drug combinations,the core drug combinations.Through this study,we can summarize the treatment rules of peri-menopausal insomnia in traditional Chinese medicine to a certain extent,and provide a reference for clinical treatment.Methods: According to the inclusion and exclusion criteria,a total of 67 articles related to the treatment of peri-menopausal insomnia with traditional chinese medicine were collected,which was published during the period of 2001-2016.The inclusion of the prescription information should be sorted out.Then,establish database and clean data.Two person were responsible for inputting data.Research results were displayed in the forms of frequency tables,pie charts,histograms,and network graph.Results: According to the statistical results of herbs frequency,a total of136 herbs were used,with a total frequency of 785 times.Semen zizyphi spinosae,caulis polygoni multiflori and radices paeoniae alba were used in the top three.According to the statistical results of herb category,the use frequency of tonic herbs is the most.Hematonic and qi-invigorating herb were used mostly.According to the statistical results of four properties,five tastes and channel distribution in Chinese herbs,neutral and warm properties were in the top two of four properties order,the sweet and bitter tastes were in the top two of five tastes order,liver,heart and kidney were in the top three of meridian entry order.According to the statistical resultsof association rules,Semen zizyphi spinosae and caulis polygoni multiflori appear most frequently,up to 19 times.The confidence level of “rhizome dioscoreae ? radix rehmanniae preparata” is the highest,92.86%.According to the core combination,24 groups of core combinations were extracted.Conclusion: 1.In recent 15 years,the most used Chinese herbs for clinical treatment of peri-menopausal insomnia is tonic herbs,followed by secative herbs and heat-clearing herbs.The Chinese herbs with neutral and warm properties,sweet and bitter tastes and meridian entry of liver,heart and kidney were most often choosen.2.The disease location of peri-menopausal insomnia mainly concerns liver,heart and kidney.The pathogenesis of peri-menopausal insomnia is deficiency of the kidney essence and the liver blood,dysfunction of the liver in maintaining the smooth movement of qi,pathogenic fire derived from stagnation of liver-qi and upward to disturb mind,dysfunction of qi and blood,disturbing the heart-shen.The treatment should be reinforcing not reducing.The main therapeutic principles of peri-menopausal insomnia are mind-tranquilizing,invigorating heart and liver,nourishing kidney-essence and dispersing stagnated liver-qi for relieving qi stagnation in clinical.3.Data mining method is an effective tool to develop traditional Chinese medicine inheritance.With the help of the traditional Chinese medicine inheritance support system to analyze the treatment rules of peri-menopausal insomnia has certain scientific.Some hidden rules could be found,then guided the clinical treatment of peri-menopausal insomnia.However,data mining also has its own limitations.