| Objective:Based on the thought of the prevention of traditional Chinese medicine "cure not ill" health care,This study selected 60 cases of the perimenopausal women with sub-health state,from the body and life of quality of life,sleep,energy,modern five aspects,we Observe inverse moxibustion "shen shu,guan yuan,sanyinjiao" points on the influence of the sub health state perimenopausal women,and explore its possible mechanism-related in order to provide a new clinical thought of preventive care in sub health state of perimenopausal women and provide women care in the community and family a simple and easy and effective method.Methods:1 the research object:the 60 perimenopausal women with sub-health status came from nanjing university of Chinese medicine affiliated hospital and community health service center in qixia district in nanjing xianlin,September 2015 and December 2016.the sixty cases were randomly divided into moxibustion group and drug group,each 30 cases,and informed to sign the consent.2 the questionnaire of index selection:Each subject was completed the contents of the questionnaire on the basic syndromes questionnaire of TCM sub-group before and after the intervention,The scores of the grading items in the questionnaire were summarized by 1-5 grade quantitative scoring method.Mainly observed in which the physical symptoms(including hot flashes,incl-uding 22),14 living conditions,7 sleep quality,emotional status of 13 andmental status of 5,the calculation of individual symptom points and total points,including sleep satisfaction Physical activity,focused on daily life and focus on attention.the higher the score,the lighter the symptoms For the res-t of the entry,the higher the score,the heavier the symptoms.3 serum specimen collection:Each studied object need before and after the intervention in the fasting time be extracted a venous blood,and competed its endocrine,immune function test.Menstrual cycle normal in menstruation2-5 days,menstrual cycle disorders or menopausal could be collected at any time.Medical staff performs on the detection of peripheral blood,including estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),Testosterone(T),pituitary prolactin(PRL)and progesterone(P)sex hormone-s and immune function of CD3+,CD4 +,CD8 +,CD4/CD8 four indicators.Sexual hormone index were measured by Beckman Kurt’s full dx1800 analyzer.Immunological parameters were detected by flow cytometry(BD).4 interventions:In inverse moxibustion group,The operator ignited moxa one end,fo-llowed by Shenshu points,Guan Yuan,Sanyinjiao points,2-3 cm distance skin smoked,smoked in skin glow as degrees,each degree 15min,daily moxibustion once,5d for a Treatment,adjacent treatment interval 2d,continuous 4 courses.The drug group was treated with daily oral administration of wheat germ oil soft capsules(Jian anxi(Shanghai)trading co.,LTD,0.308 g per tablet),after dinner everyday,a total of 28 days.Results:1.In inverse Moxibustion group,The main physical symptoms and the symptoms integral of fatigue,lethargy,hot flushes was significantly different from those before the intervention(P<0.01).In the moxibustion group,before and after the intervention,fatigue degree of ease,heavy legs,bitter mouth,spontaneous sweating,night sweats,flustered,chest tightness,shortness of breath and other eight symptoms integral.had obvious difference;However,the total integral of the main body and the integral of fatigue,fatigue degree of ease,hot flushes were lower than the drug group(P<0.05).2.The total score of living conditions of moxibustion intervention were statistically significant compared with that before intervention(P<0.01),which was superior to the drug group(P<0.05).The night to urinate symptoms integral comparison before and after moxibustion had significant difference(P<0.01),loose stool pond have obvious difference(P<0.05),after intervention at night to urinate in inverse moxibustion group was lower than that in group drugs.3.Compared with before intervention,the total score of sleep mass and sleep satisfaction score after inverse moxibustion had significant difference(P<0.01).Mainly in difficulty falling asleep,easy to wake up at night symptoms improved significantly(P<0.05);After intervention,the antimoxial group was better than the drug group(P<0.05).4.The total score of energetic symptom before and after intervention of moxibustion was a obvious significance(P<0.05).which is lower than the drug group(P<0.05).The integral inverse effect before and after moxibustion have obvious difference(P<0.05),lower productivity before and afterhad significant difference(P<0.01),and after the intervention inverse moxibustion groups on the efficiency of integral is lower than the drug group(P<0.05).5.Inverse moxibustion before and after the intervention,the total integral of emotion symptoms and life significance feeling symptoms integral had significant significance(P<0.01),while the mood calm and empty heart symptoms integral had obvious difference(P<0.05);Moreover,in the anti-moxibustion group,the overall score,mood,and sense of life was significantly better than the drug group(P<0.05).6.Compared with moxibustion,in moxibustion group,content level of serum E2,P,T was higher,which was statistically significant(P<0.05),but the content of FSH,LH levels drop was statistically significant(P<0.05);And after the intervention inverse moxibustion serum E2,P,T levels higher than the drug group,and FSH levels lower than the drug group(P<0.05),with the menopause after inverse moxibustion E2,FSH,LH,P,T have significant statistical significance(P<0.05),and after the intervention inverse moxibustion group of E2,P,T content is higher than that of drug group,FSH levels lower than the drug group(P<0.05);The postmenopausal were less effective than the non-menopausal(P>0.05).7.After inverse moxibustion,in moxibustion group,CD3 + was a significant differences(P<0.01),CD4 +,CD4 +/CD8 + inverse effect before and after moxibustion had a obvious significance(P<0.05),which is superior to drug group(P<0.05).Not-menopause,before and after the intervention,CD3 +,CD4 +/CD8 + had obvious difference(P<0.05),the postmenopausal inverse moxibustion,CD3 +,CD4 + had obvious difference before and after intervention(P<0.05),while CD3 +from the menopause had a superior to postmenopausal(P<0.05).Conclusion:Anti-moxibustion Guan Yuan,Sanyinjiao,Shenyu group not only benignly regulated the perimenopausal sub-healthy female sex hormone levels,but also through the endocrine immune network system to improve immune function and enhance physical fitness.At the same time,which alleviated the female body symptoms at this stage,effectively improved sleep Quality,adjustd the emotional state,enhanced the state of energy.Fully explained that the anti-moxibustion could regulate the body’s own nerve-endocrine-immune network,with the improvement of perimenopausal women’s quality of life,delay or even avoid the occurrence of perimenopausal syndrome,worthy of community,family promotion and application. |
