| Objective:to detect serum tumor necrosis factor-a (TNF-a), interleukin-18 (IL-18), Adiponectin (ADPN) and fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), Urinary albumin excretion rates (UAER) and other indicators in Patients with type 2 diabetic nephropathy. Explore type 2 diabetes nephrosis patient serum TNF-a, IL-18, ADPN level of change and its affecting factors and the relationship between them.Methods:randomly selected from October 2010 to February 2011 received treatment in China-Japan Union Hospital of Jilin University, outpatient clinic or ward and the patients diagnosed as 50 cases of T2DM. According to UAER were divided into 2 groups:Diabetic patients without nephropathy (NDN group) 25 cases; Diabetic nephropathy (DN group) 25 cases. and set the 25 cases of normal control group (CTL group).All subjects detected TNF-a, IL-18, ADPN, FBG, HbAlc and UAER and other indicators, Compare the differences between the groups of indicators, and the TNF-α, IL-18, ADPN and Correlation Analysis of other indicators.Results:(1) the DN group, the NDN group and the CTL group's sex, the age, the course, the body weight index constitution compares does not have statistics difference (P>0.05), three groups of material have the commeasurability. (2) FBG, HbA1C in NDN group and DN group was significantly higher than CTL group, the differetnce was statistically significant (P<0.05); FBG and HbA1C in DN group slightly higher than the NDN group compared with diabetes in each group, but the difference was not statistically significant (P> 0.05);UAER in DN group significantly higher than NDN group and CTL group, the difference was statistically significant (P<0.01), NDN group UAER slightly higher than the CTL group, but the difference was not statistically significant (P> 0.05). (3) TNF-a in DN group and NDN group were significantly higher than the CTL group, the difference was statistically significant (P<0.05);compared with diabetes in each group, DN group was significantly higher than that of TNF-a NDN group, the difference was statistically significance (P<0.05);IL-18 in DN group and NDN group were significantly higher than the CTL group, the difference was statistically significant (P<0.05);compared with diabetes in each group, DN group was significantly higher than that of IL-18 NDN group, the difference was statistically significant (P<0.05);ADPN in DN group was significantly higher than NDN group and the CTL group, the difference was statistically significant (P<0.05); ADPN in NDN group lower than the CTL group, the difference was statistically significant (P<0.05). (4)In type 2 diabetic patients, serum TNF-a and FBG, HbAIC, UAER was significantly correlated, the differences were statistically significant (P<0.05, P <0.01, P<0.01); IL-18 and the FBG, HbAIC, UAER was a significant positive correlation, the differences were statistically significant (P values<0.01); ADPN and UAER was significantly correlated (P<0.01), and BMI, FBG, HbAl was a negative correlation(P values<0.05).Conclusions:(1) Serum TNF-a, IL-18, ADPN significantly higher than healthy people in patients with type 2 diabetic nephropathy, and with the increase of UAER increased, suggesting that Inflammation participated in the diabetic nephropathy occurrence, development process. (2) Serum TNF-a, IL-18, ADPN were correlated with the pathological stage of diabetic nephropathy. (3) Serum TNF-a, IL-18, ADPN level can be used as glucose metabolism in patients with type 2 diabetes control is good or not state one of the indicators. (4) for type 2 diabetes patients, we should be strict control of blood sugar, dynamic observation of serum TNF-a,IL-18,ADPN and other inflammatory-related factors, and urinary protein excretion rate and other indicators.This will help early detection and prevention of the occurrence and development of DN, decrease the risk of death and disability in patients with diabetes. |
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