Investigation Of 20456 Jilin Visiting Women High Risk HPV Detection In The First Hospital Of Jilin University

Background: In contemporary society,the incidence of cervical cancer is mostly chanced among the yonuger,shortening the disease process,and increasing year by year.WHO(World Health Organization)through the investigation and analysis found that women around the world caused by cancer mortality in the population of cervical carcinoma was second,rank only second to breast carcinoma.In some economically backward areas,cervical cancer and even become a threat to women's health of the first cancer killer.It will appear new around five hundred thousand of patients with cervical cancer each year mondial,which kills about more than 270.000,cervical cancer has become the most important lethal factors around women around the age of forty.In our country,the number of new cases of cervical cancer every year is about one hundred and thirty thousand,of which about two to thirty thousand of women died of cervical cancer,and the number continues to rise year by year.Even more alarming is that,although Chinese patients with cervical cancer in the distribution of more than thirty-five years old,reached its peak in the age of women before and after menopause,but the twenty year old to twenty-five year old patients with cervical cancer also occupy a certain proportion,young women also slowly began to receive the threat of cervical cancer.With the development of society,people for the census of more in-depth understanding,early detection of cervical cancer has also been considerable development,the corresponding treatment technology is gradually mature,cervical cancer has been controlled to a certain extent.In the last century in 50 s,China established a cervical cancer screening system,twenty years after the death rate of cervical cancer in China decreased by about seventy percent.However,we also find that the city female cervical cancer prevalence was obviously improved,but in rural areas to improve the situation is not very obvious,in the Midwest of China in some poor areas,the death rate of patients with cervical cancer is still high,such as Shanxi Province,Gansu province in some areas,cervical cancer mortality rate has reached 36/100000.More than ten times the average level of our country,is about four times the world average death rate.The death rate of cervical cancer showed obvious regional characteristics,the reason is one of the most important causes of social development: cervical cancer population in women,dirty sex female,poor sanitation,poor mountainous areas,remote areas such as the flow of city in females probability and mortality rates were relatively high.Compared to the whole world,the incidence of cervical cancer in China has been at the forefront,and there is a trend of increasing year by year.Jilin province is located in the northeast of China,the incidence of cervical cancer can not be ignored,and each subtype of HPV has its own particularity.Therefore,to understand the situation of human papilloma virus infection Jilin nipple,survey which isoforms proportion and distribution state,in the days after the cervical cancer screening and prevention and early treatment work are very meaningful.Objective:To inestigate the distribution and subtype distribution of high risk HPV infection among women in obstetrics and gynecology in Jilin Provience,and to reflect the situation of HPV infection among women.To clarify the significance of HC2-HPV DNA in the early diagnosis and screening of cervical cancer,to master the distribution characteristics of HPV infection in different levels of population,and to explore the distribution of high-risk HPV infection.Risk factors of cervical cancer in patients with cervical precancerous lesions and cervical cancer.To provide clinical evidence for the prevention and treatment of cervical precancerous lesions and cervical cancer.To provide data for large-scale HPV infection investigation in Jilin Provience.To provide reference for the selection of HPV vaccine in the region.Methods: Select the women to visit doctor and make physical examination at Jilin University Hospital from March 2016 to February 2017 in Jilin provience.A total of 20456 patients were examined with routine TBS standard for routine ThinPrep cytology.Second generation hybrid capture technique(HC2)for screening high risk HPV,and the prevalence of HPV infection and subtype distribution were investigated.The diagnostic criteria of TBS classification of cervical cytology positive and / or HPV DNA positive patients with 400 cases of colposcopy and biopsy,in order to diagnose cervical disease early,and of all the subjects of statistics and analysis of the rate and subtype distribution of high-risk HPV infection.Results: The risk of HPV infection was 23.89% in patients in our hospital in Jilin,Some patients with cervical lesions and cervical cancer can often detect multiple HPV infection at the same time.The positive rate of HC2-HPV-DNA increased with the severity of cervical lesions.Cervical intraepithelial lesions in CIN I and CIN II ~ III and the positive rate of cervical cancer in high-risk patients with type HPV were significantly higher than those in patients with cervicitis,women above 35 high-risk HPV infection rate was significantly lower than those under the age of 35,the infection rate of rural women high-risk HPV is slightly higher than that of city residents,the high income rate is lower than the low income.With aoolication of card examination,P < 0.05,the difference was statistically significant.Conclusion: The high risk HPV infection rate of female in Jilin is 23.89%,which is consistent with the domestic high risk HPV infection.The results of univariate analysis showed that the age,the level of per capita income,the difference between urban and rural residential areas,and multiple sexual partners,premature delivery,whehter contraceptiong were the risk factors for HPV infection.From the perspective of prevention and treatment of cervical cancer,we should strengthen the screening of cervical cancer.On one hand,we should strengthen the publicity and educate these women with cancer preventing and health caring knowledge.In order to enable these people to know the risk factors and early signs of cervical cancer,so it could nip in the bud.On the other hand,making scientific and reliable screening,such as screening of high-risk HPV combined with liquid based cytology in our country at present,to timely detect the stage of cervical precancerous lesions,to early diagnosis and early treatment the disease,reduce the morbidity and mortality of cervical cancer.