| Object:Through observing the impact of Huotantongbi Decoction on blood lipid levels,symptoms of angina and Traditional Chinese Medicine syndrome scores in patients with coronary heart disease after pertaneous coronary intervention and phlegm and blood stasis syndrome,to evaluate the clinical curative effect of Huotantongbi Decoction.Methods:According to the admission criteria,60 patients with coronary heart disease after PCI and phlegm and blood stasis syndrome were chosen.The patients were randomly divided into one treatment group(given conventional treatment of western medicine + Huotantongbi Decoction)composed of 30 cases and one control group(given conventional treatment of western medicine)composed of 30 cases.The course of treatment was 3 months for both groups.Observation of the changes in blood lipid levels,angina symptoms and Traditional Chinese Medicine(TCM)syndrome score was made before and after treatment of the patients in the two groups.Results:(1)Index related to blood lipid:blood lipid levels(TG?TC?HDL-C?LDL-C)in both groups improved significantly after treatment(The treatment group:1.73±0.74,4.38±0.94,1.23±0.31,3.11 ±0.76 vs 0.96±0.29,2.86±0.51,1.53±0.44,1.36±0.34;the control group:1.88±0.82,4.67±0.86,1.18±0.31,3.11±0.72 vs 1.32±0.66,3.40±0.82,1.46±0.53,1.62±0.42)and this shows statistical difference compared with the condition before treatment(P<0.05);the treatment group cases of TC(2.86±0.51 vs 3.40±0.82)?LDL-C(1.36±0.34 vs 1.62±0.42)was significantly lower(P<0.01),the TG(0.96±0.29 vs 1.32±0.66)was lower than that in the control group(P<0.05),while the HDL-C(1.53 ±0.44 vs 1.62 ±0.42)has no statistical difference between the two groups(P>0.05).(2)The curative effect on angina:both groups could improve symptoms of angina.The total effective rate is 90%in the treatment group and 83.3%in the control group.The treatment group was better than the control group,but there was no statistical difference between the two groups(P>0.05).(3)TCM syndrome score:The improvement of TCM syndrome score after treatment in the two groups(The treatment group:25.87±3.17 vs 9.93±1.80,the control group:25.57±2.58 vs 13.03±2.36)showed significant statistical difference(P<0.01)and the improvement of TCM syndrome score(9.93±1.80 vs 13.03±2.36)in the treatment group was lower than that in the control group(P<0.01),And the the treatment group is better than the control one at improving symptoms of chest stuffiness(1.87±1.04 vs 2.53±1.04)and vomiting phlegm(0.87±1.01 vs1.60±1.10)(P<0.05).(4)The observation of safety indicators:There were no significant abnormal changes reflected in blood routine and liver and kidney function examinations during the period of treatment in both groups;no muscle pain,allergies,fatal bleeding,stent thrombosis or other adverse reactions occurred in both groups of patients;this shows that in the conventional Western medicine treatment based on the addition of Huotantongbi Decotion has good safety and tolerance.Conclusion:On the basis of conventional western medicine treatment,the addition of Huotantongbi Decoction can further optimize blood lipid levels and improve TCM syndrome scores in patients with coronary heart disease after PCI,its safety and effectiveness are worthy of recognition. |
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