Glucose And Lipid Metabolism And Coronry Heart Disease And The Extent Of Coronary Artery Disease Research

Objective:To investigate the relationship between blood glucose, blood lipid and coronary heart disease, coronary artery lesions.Methods:Collected from May 2012 to December 2014 during the First Affiliated Hospital of Guangxi Medical Institute 1307 cases because patients are hospitalized with suspected coronary angiography,1005 cases were male, female 305 cases. According to the 1979 WHO criteria for the diagnosis of coronary heart disease, coronary angiography positive (main vessel diameter stenosis 50%) as the standard of the diagnosis of coronary heart disease, coronary heart disease group of 1167 cases, excluding those with coronary heart disease (coronary smooth surface) of the 140 patients in the control group. The severity of coronary artery lesion by Gensini integral evaluation. The general condition of the patients:age, gender, smoking history, drinking history, history of diabetes, history of hypertension such as detailed records. Preoperative fasting venous blood samples were collected for the night, fasting blood glucose, glycosylated hemoglobin,2 hour postprandial blood glucose, total cholesterol, glycerin three greases, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A1, apolipoprotein B, lipoprotein (a) and homocysteine. Relationship between different groups of glucose levels of blood glucose and blood lipid levels and the incidence of coronary heart disease and the severity of coronary artery lesions. To data processing and analysis by SPSS16.0 software, P< 0.05 was considered statistically significant.Results:(1) CHD group of TC, TG, LDL-C, apoB, LP (a), Hey, FBG, PBG2h, HbA1c were higher than the control group, the difference had statistical significance (P<0.05); HDL-C, apoAl CHD group were lower than the control group, the differences were statistically significant (P<0.05).(2) TC, TG, HDL-C, LDL-C, apoAl, apoB, Lp (a), Hey, FBG, PBG2h, HbA1c compare overall statistically significant (P<0.05) between the different components of the degree of coronary artery disease further analysis of the components of multiple comparisons were several display apoAl, HbA1c were significantly different (P<0.05), apoAl negatively correlated with coronary artery disease, HbAlc and coronary artery lesions were positively correlated. (3) Age, hypertension, smoking, LDL-C, Hcy, FPG, PBG2h were risk factors for coronary heart disease, and apoAl protective factors for coronary heart disease. (4) Age, BMI, TC, TG, LDL-C, apoB and LP (a), Hcy, FBG, pbg2h, HbAlc and coronary vessels were correlated positively with Gensini integral. HDL-C, ApoAl and Gensini score was negatively correlated. (5) ApoAl is an independent factor negatively correlated Gensini integration. ApoB, HbA1c, age, Lp (a), BMI, Hey are Gensini integral independent positive correlationfactors.Conclusion:1. Patients with coronary heart disease (CHD) in glucose and lipid metabolism than non coronary heart disease patients with significant difference. The higher degree of coronary artery lesions in patients with coronary heart disease the glucose and lipid metabolism disorders is more obvious.2. Age, history of hypertension, smoking history, LDL-C, Hcy, fasting blood glucose, postprandial 2H plasma glucose are risk factors for coronary heart disease (CHD). ApoAl is protective factor for coronary heart disease.