Study Of The Relationship Between Blood Lipid Comprehensive Index And The Risk Of Coronary Heart Disease

Objective:The distribution of patients with coronary heart disease in hospital was investigated by analyzing case on patients with coronary heart disease(CHD) in Department of Cardiology. The relationship between conventional index for blood lipids(TC, TG, HDL, LDL) with blood lipid comprehensive index(LCI, AIP, non-HDL) and CHD was discussed, which would be useful on theoretical basis of CHD diagnosis strategy.Methods:1.The overall distribution of hospitalized patients with CHDThe research object consist of 5125 hospitalized patients diagnosed with CHD from Changzhi medical college affiliated hospital in 2011.1-2014.12. The medical record data including name, sex, date of birth, occupation, address, main diagnosis, blood lipid conventional detection index(TG, TC, HDL- C, LDL-C) and date of detection. The case must be real and reliable. The general characteristics of patients with CHD were analyzed through descriptive analysis. The age and sex of patients with CHD were analyzed through chi-square test with SPSS17.0 software.2. Comparison of general data and serum lipid in patients with CHD and non CHDAccording to the results of coronary angiography, the patients were divided into CHD group and non CHD group. 4829 cases of CHD group include 3423 cases of male [average age(57.37±11.64)], 1406 cases of femal [average age(63.67±9.95)]. 3579 cases of non CHD group include include 1809 cases of the male [average age(57.84±15.18)], 1770 cases of female[average(59.20±14.19)]. The blood routine index(TC, TG, HDL-C, LDL-C), comprehensive index of blood lipid(LCI, AIP, non-HDL) were analyzed through case-control study method with SPSS17.0 software. The basic information and lipid parameters between the CHD group and non CHD group were analyzed with t test and non univariate nonparametric test, and the relationship between the indexes of blood lipid and CHD were analyzed with non conditional logistic regression analysis.Results:The results of this study are as follows:1.The overall distribution of hospitalized patients with CHD(1) This study collected a total of 5125 patients with CHD, which the age ranged from 12 to 93. The average age was 60.06±11.43. The number of patients in hospital increased by 14% between 2011~2013, however, the number of hospitalized patients decreased slightly in 2014.(2) The percent of 60-74 years old patients is 42.03% in the Department of Cardiology, which presented a significant decreasing trend(χ2=4.163,P<0.05). The percent of 45~59 years old patients is 37.83% in the Department of Cardiology, which presented a significant increasing trend(χ2=6.436,P<0.05).(3) The incidence of this CHD in males is higher than in female, and the constituent ratio of male and female is greater than 2:1. According to the occupational distribution, the percentage of agricultural labourers and workers is 42.46 and 12.92, respectively.2. The comparision of general data and serum lipids in patients with CHD and non CHD(1) TC and TG in patients with CHD group are higher than that of non CHD group, while HDL-C was lower than that in non CHD patients, and the difference was statistically significant(Z=-2.110,P=0.006;Z=-17.829,P<0.001;Z=-4.583,P<0.001). According to age stratification analysis, the LCI and AIP index in people of all ages coronary of CHD group are higher than non CHD group(Z=-10.968,P<0.001;Z=-16.216,P<0.001;Z=-4.352,P<0.001), and non HDL index of over 60 years old age from CHD group is higher than that from non CHD group(P<0.05). The LCI, AIP and non HDL index in CHD group are higher than that in non CHD group(P<0.05), the differences were statistically significant.(2) Non conditional logistic multi factor analysis of CHD, the results showed that the increase of TG is the risk factor of CHD(OR=1.449, 95%CI:1.100~1.355) after controlling for age, gender, occupational factors. The increase of lipid comprehensive index AIP value(OR=3.671, 95%CI: 3.005~4.484) was used to diagnose as CHD.Conclusion:(1) The number of hospitalized patients with CHD is increasing year by year in Department of Cardiology.(2) Among of hospitalized patients with CHD, the elderly people accounted for a large proportion, and the prevalence of younger age is increasing.(3) The incidence rate of male patients is obviously higher than that of female.(4) The comprehensive index of blood lipid in CHD patients are significantly higher than that in non CHD patients, and the comprehensive index sensitivity is higher than conventional indicators in different age and gender groups.(5) There are more closely relationship between AIP index of lipid comprehensive index and CHD.