The Clinical Research Of Chinese Traditional Syndrome Between Before And After The Chemotherapy Treatment Of TP In Advanced Non-Small Cell Lung Cancer

Purpose:Prospective method of research is used in this study,by observing TCM syndrome different characteristics before and after TP chemotherapy in advanced non-small lung cancer patients,to explore the pathogenesis of lung cancer,the evolution of TCM syndrome and the best opportunity of TCM treatment.The results would provide important theoretical basis for the clinical diagnosis and treatment of advanced non-small lung cancer.Method:We choose 50 cases of advanced non-small lung cancer patients who were diagnosed in Jiangsu Province Hospital and Jiangsu Province Tumor Hospital ward and outpatient department from April 2016 to December 2016.We record 50 patients'symptoms,signs,tongue,pulse and so on of 7 days before and 8 days,15 days after TP chemotherapy though questionnaire form,then classify them into different TCM syndrome types according to the diagnostic criteria of TCM.The database was established by SPSS20.0 to analysis the change regulation of TCM syndromes before and after chemotherapy.Count data was checked by chi-square test,measurement data was checked by analysis of variance,P<0.05 is regarded as statistical difference.Result:(1)There is no significant difference in the incidence between male and female.The age of 61-70 is a high incidence populationt,and the incidence rate of people over the age of 50 is higher than those under the age of 50.(2)There is no significant difference in age,sex and TCM syndromes in?B and ? non-small cell lung cancer patients.(3)7 days before chemotherapy,symptoms such as cough,excessive and sticky phlegm,blood in phlegm,fatigue,chest distress and asthma are mostly seen.Pale red tongue,white greasy are the most.accounting for 50%,48%respectively,red tongue,thin white coating followed,accounting for 28%,22%,20%respectively.Pulse is mainly slippery pulse,accounting for 38%,then is thready and weak pulse,accounting for 24%.TCM syndrome is mainly marked with the syndrome of phlegm dampness,the syndrome of Qi deficiency,and the syndrome of yin deficiency and internal heat for 38%,22%,20%respectively.(4)8 days after chemotherapy,TP chemotherapy can relieve patients of cough,blood in phlegm,chest pain,chest distress,asthma and other lung related symptoms.And the occurrence rate of poor appetite,nausea and vomitting,hair loss,arthralgia,deadlimb,dry eye,dry stools etc such symptoms is obviously increased.Pale red tongue and white and greasy coating are reduced to 26%,20%,little coating,red tongue and teeth-maked tongue are increased to 42%,38%,24%respectively,yellow greasy coating and dark purple tongue also increase slightly.Slippery pulse is decreased to 12%apparently,the proportion of count pulse and thready and weak pulse shows a upward trend,up to 30%and 40%.Correspondingly,phlegm dampness syndrome and Qi deficiency syndrome reduce to 20%,10%.The syndrome of Qi and yin deficiency,the syndrome of yin deficiency and internal heat are increased compared to before chemotherapy,accounting for 32%,26%.(5)15 days after chemotherapy,TCM syndrome is mainly manifested as the syndrome of phlegm dampness and the syndrome of Qi deficiency decreased,the syndrome of Qi and yin deficiency and the syndrome of yin deficiency and internal heat increased.In addition,the syndrome of blood stasis obstructing the lung is up to 10%.But comparing witih 8 days after chemotherapy,nausea and vomitting,poor appetite etc alimentary symptoms relieve obviously.Conclusion:There is a certain pattern in the TCM syndrome changes before and after TP regimen chemotherapy in advanced non-small lung cancer.Before chemotherapy,it is mainly manifested as the syndrome of phlegm dampness,the syndrome of Qi deficiency and the syndrome of yin deficiency and internal heat also occupy a certain proportion.After chemotherapy phlegm dampness syndrome and Qi deficiency syndrome reduce obviously,the syndrome of Qi and yin deficiency,the syndrome of yin deficiency and internal heat increase compared to before chemotherapy.It shows that TP regimen(paclitaxel combined with DDP)is toxic heat of goods,results to the consumption of Qi and yin and injury of liver and kidney.So,take the TP chemotherapy patients can advanceto Tonifying Qi,nourishing Yin,clearing heat,nourishing liver and kidney,and activating blood circulation and removing blood stasis.