| Patient 's most common symptomatic symptoms, nasal obstruction, itch, nasal itching, embolism, possible impacts patient's life mass. Immediate clinical progression AR diagnostic method, inclusive SPT, serum specificity IgE measurement, EOS etc.SPT is influenced by many factors, such as drug, skin and subjective judgment of the patient. Serum specific IgE takes a long time, and it can not meet the growing needs of AR patients. The EOS ratio and absolute value of peripheral blood in patients with AR can be high and low, and there is no specificity. Immediately at our hospital AR Patient One - Line Recommendation Recommended Use Nose for Fast Night White and Three Dresses. Violent type for nasal use, occupational diagnosis Main usage Nose for use for nose Suicide pesticide, We are the general manager of clinical treatment,progressive progression, observation and treatment treatment failed party interviewee production effect.At present, the pathogenesis of AR we are unanimously respected, for the expression of Th2 cytokines excessive, our experimental group inspired by this, can directly test Th2 cytokines in patients with clinically, the results as the gold standard for diagnosis of AR. Through the establishment of AR animal model, the study of Th2 cytokines in the pathogenesis of AR in the role, is the significance of this study, the pathogenesis of AR not only can more effectively, to overcome some limitations of the experiment directly provide new insights into human diagnosis and the treatment of AR.There are many kinds of cytokines in Th2, which is the main obstacle to our experiment. Studies have shown that IL-6 and IL-10 play a positive regulatory role in the AR reaction, secretion is extremely strong. This shows the way to our experiment,our AR animal model will study the two cytokines of IL-6 and IL-10.Objective: The establishment of AR model in guinea pig and the detection of IL-6 and IL-10 cytokines, and observe the clinic on the examination method for the diagnosis of AR and treated with mometasone furoate and montelukast tablets in the treatment of the clinical efficacy of Turner.Methods: AR control group of 48 cases, mometasone furoate the nostrils of each spray, spray once daily in the morning, a total of 2 injection, 2 weeks of continuous use;Loratadine Tablets 10mg orally once every night. 46 cases of patients in the experimental group, the application of mometasone furoate and Loratadine Tablets treatment method with the control group, treated with montelukast tablets daily before bedtime a lOmg. For 2 weeks. The symptom adopts 0-3 point scoring method, the curative effect standard is divided into three grades: marked effect, effective and ineffective. The symptom changes and curative effect before and after 2 weeks were observed.Selection of 20 Hartley of guinea pigs as animal, ovalbumin as allergens,aluminum hydroxide as adjuvant, the experiment was divided into two stages, the first is systemic sensitization, experimental groups of guinea pigs were injected OVA mixed suspension; the second stage is the nose will stimulate, soluble ovalbumin per nostril was used for intranasal approach to experiment guinea pigs in the control group were treated with 0.9% normal saline in guinea pigs. Then, by observing the sneezing and scratching nose symptoms to determine whether the success of the model, the high counts of eosinophils and the use of guinea pig kit to detect IL-6 and IL-10. Clinical AR patients in the control group were treated with mometasone furoate, the nostrils spray, spray once daily in the morning, a total of 2 injection, 2 weeks of continuous use,the experimental group of mometasone furoate treatment with the control group,treated with montelukast tablets orally at bedtime, daily one, a total of 2 weeks.Results: AR patients in the control group of 48 people, age 37.60 + 12.94 years old, experimental group 46 people, age 38.04 + 15.27 years old, P=0.134, two groups of age difference is not statistically significant. The results of EOS in the control group were (0.07 + 0.05); the results of EOS in the experimental group were (0.05 + 0.02),P=0.002. After treatment the experimental group of patients with AR symptoms score results for (83.48 + 11.05)%, the control group improved symptoms score was (51.25 +21.08)%, improvement of symptoms were two groups after treatment, and the experimental group after the treatment of symptoms than the control group, the differences were statistically significant (P=0.000).The experimental groups of guinea pigs were sensitized and challenged after frequent nasal itching (the nose), sneezing,t-ching behavior, experimental group's success rate is 60%, The experimental group than control group in the nasal mucosa eosinophil infiltration increased significantly (P< 0.05). The IL-6 level of experimental group nasal mucosa was (185.41 + 9.57) ng/L,IL-10 level (99.97 + 12.71) ng/L, compared with the control group, IL-6 level (4.35 +0.30) ng/L, IL-10 (4.45 + 0.31) ng/L increased significantly (P < 0.05).Conclusions: Momison, Loratadine Tablets and the effect of furoic acid treatment of AR better than Montelukast Sodium Tablets and Loratadine Tablets for Momison furoic acid. The AR guinea pig model was successful. Th2 cytokines, IL-6 and IL-10 in AR guinea pigs were higher. |
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