Clinical Observation Of Guba Decoction To Treat Soft Tissue Contusion In Early Phase Of Distal Humeral Fractures

ObjectiveTo observe the clinical curative effect of Guba decoction to treat soft tissue contusion in early phase of distal humeral fractures.MethodsThe prospective randomized controlled clinical trial method was adopted in this study.From February 2016 to January 2017,80 patients of closed distal humeral fractures in early phase who were in the orthopedic hospital treatment of Foshan hospital of TCM were randomly divided into experimental group and control group with 40 cases in each group,according to the inclusion criteria.Two groups were be cured the same conventional and basic therapy,such as taking the Sanqi Huayu oral liquid,QuShang tablets,injured limb external application of the Yellow Water yarn and maintain the plywood external fixation,guiding patients with functional exercise etc.On this basis,the experimental group was treated with Gubadecoction once daily while the control group was not treated with any Chinese medicine decoction and only used the basic treatment.The observational period of treatment is one week.Two groups of objects were observed the change of outcome respectively,such as VAS pain scores and the injured limb swelling situation before treatment and on the 3th,7th day after therapy.The content of inflammation factor interleukin 6(IL-6)and tumor necrosis factor(TNF-a)as well as soft tissue injury symptom classifying quantization integrals were observed before and after the treatment.The data was recored and made with statistical analysis,objectively evaluating the efficacy and safety of Guba decoction.Results1.There were no significant differences in general conditions such as gender composition,age distribution,clinical time,causes of injuries,injury sides,fracture classification of AO between the experimental group and the control group(P>0.05),which suggested the baseline of the two groups was balanced and comparable.2.There were no significant differences in VAS pain scores and the injured limb swelling situation between the two groups before treatment(P>0.05),which suggested the two groups were comparable.After treatment,two groups of VAS pain scores and the injured limb swelling situation were improved(P<0.05 or 0.01).The VAS pain scores of the two groups decreased with the passage of time,and the difference was statistically significant(P<0.05 or 0.01).The injured limb swelling situation of the two groups increased with the increase of time and then decreased,and the difference was statistically significant(P<0.05 or 0.01).In the third and seventh day of the treatment,the VAS pain scores and the injured limb swelling situation in the experimental group were all lower than the control group(P<0.05 or 0.01).3.There were no significant differences in IL-6,TNF-? content and soft tissue injury symptom classifying quantization integrals between the two groups before treatment(P>0.05),which suggested the two groups were comparable.After treatment,the levels of IL-6,TNF-? and soft tissue injury symptom classifying quantization integrals were decreased in both groups,and the differences were statistically significant(P<0.01).After therapy,the differences were statistically significant between the two groups(P<0.01).The experimental group was better than the control group in lowering the the concentration of IL-6,TNF-? and soft tissue injury symptom classifying quantization integrals.4.The significant efficiency of the experimental group was 42.5%,and the total effective rate was 87.5%.While in the control group,the significant efficiency of the experimental group was 17.5%,and the total effective rate was 77.5%.The clinical efficacy of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was low in the two groups,and there were no significant differences between the two groups(P>0.05).ConclusionGuba decoction to treat soft tissue contusion in early phase of distal humeral fractures is effective,which can effectively relieve the pain of the injured limb,rapidly reduce the swelling of the limb,reduce the inflammatory factor IL-6,TNF-? content to inhibit the inflammatory response,lower the soft tissue injury symptom classifying quantization integrals.The therapy is safety with no obvious adverse reactions and worthy of clinical promotion.