Features And Influencing Factors Concerning The Ecological Executive Function Of Adult Epileptics

Objective Epilepsy is a familiar disease of the nervous system can be caused by a variety of reasons,clinical manifestations of seizures,transient characteristics,repetitive and stereotyped,which is characterized by highly synchronous abnormal discharge of brain neurons.Executive function is a kind of advanced cognitive function.The patients with executive dysfunction have some problems,such as the psychological and social function,the decline of educational achievement and the difficulty of finding a job.Epilepsy patients with executive dysfunction has been widely recognized.In the past,more research has been conducted to evaluate the executive function of patients with epilepsy by the use of an operational neuropsychological test,which can not fully reflect the actual executive function of patients with epilepsy.It is short of of ecological validity.Compared with the neuropsychological test,the executive function rating scale has good ecological validity,and has been used in schizophrenia,attention deficit hyperactivity disorder(ADHD),traumatic brain injury and other diseases.The main purpose of the research used the Behavior Rating Inventory of Executive Function-adult version(BRIEF-A)was:(1)Whether patients with epilepsy are ecological executive dysfunction;(2)To explore the influence causes of executive dysfunction.Methods120 adults with idiopathic or probably symptomatic epilepsy were compared strictly with 120 healthy controls of the same gender,age,and educational degree.The discrepancies in ecological executive function were contrasted between the case group and matched group with the Behavior Rating Inventory of Executive Function-adult version(BRIEF-A);apply multiple stepwise linear regression analysis to explore the correlations between clinical features of epileptic patients with projects of BRIEF-A.Results:By contrast,the patients had higher scores on all projects of BRIEF-A(P<0.05):gl obal executive composite(GEC)[(54.41±8.92)vs(47.83±5.35)],behavioral regulation index(BRI)[(56.77±7.81)vs(49.61±5.63)],inhibition[(53.73±8.62)vs(47.89±6.46)],shift[(58.75±9.82)vs(52.48±7.78)],emotion control[(56.57±7.86)vs(49.48±5.68)],self-monit oring[(53.01±10.42)vs(48.22±6.43)],metacognition index(MI)[(52.84±10.56)vs(46.80±5.48)],initiation[(50.94±10.23)vs(46.33±6.63)],working memory[(55.68±10.31)vs(49.65±7.19)],plan[(53.12±9.54)vs(47.43±5.57)],organization[(47.40±8.65)vs(44.42±5.19)],task monitor[(53.68±9.35)vs(49.72±6.89)].Multiple stepwise linear regression ana lysis revealed four clinical features that were seizure type,seizure frequency,epilepsy control and antiepileptic drugs were closely related to BRIEF-A while factors such as course of disease,gender,age,marriage,educational degree,initial age were not closed to BRIEF-A.ConclusionAdults with idiopathic or probably symptomatic epilepsy have ecological executiv e dysfunctions and is affected by seizure type,seizure frequency,epilepsy control a nd antiepileptic drugs.