Based On Analysis Of Sticky Protein Research Clinical Characteristic Of AECOPD (Lung Disease Temper Deficiency Syndrome)

Objective:Detection of sputum in patients with chronic obstructive pulmonary disease and normal controls MUC5AC?MUC5B and Content of related media,Analysisv inflammatory mediators And other indicators of the number of differences in AECOPD?Stable stage of chronic obstructive pulmonary disease(Lung spleen qi deficiency syndrome)and normal control group MUC5AC?MUC5B.Reveal AECOPD changes in the state of airway mucus and mucin and The role of mucin in the evaluation of patients with chronic obstructive pulmonary disease.Explain the closely related between Abnormal secretion of mucin and COPD frequent acute plus heavy.to provide reference for clinical classification treatment,In order to elaborate“The spleen is the source of phlegm and the lung is the device for storing phlegm”chinese medicine theory to provide a scientific basis for research.Methods:Method for inducing sputum in 120 patients with chronic obstructive pulmonary disease and 60 normal persons,isolated sputum specimen,and than conduct cell count and classification;The sputum supernatant were separated by enzyme linked immunosorbent assay(ELISA)Testing the MUC5AC?MUC5B.Results:Chronic obstructive pulmonary disease?AECOPD?Normal control group,the MUC5AC?MUC5B in patients with chronic obstructive pulmonary disease are increase,There was significant difference between the three groups(P<0.05),among them,the induced sputum increased in the acute exacerbation of COPD,and the stability of chronic obstructive pulmonary disease decreased,there was significant difference between COPD and acute control group(P<0.05),there was significant difference between chronic obstructive pulmonary disease and control group(P<0.05),In the induced sputum,neutrophils,lymphocytes,macrophages and eosinophils were higher than those in the control group,the difference between the three groups was statistically significant.Conclusion:MUC5AC?MUC5B and inflammatory mediators are i involved in the pathogenesis of chronic obstructive pulmonary disease,abnormal secretion of mucin is closely related to chronic obstructive pulmonary disease is the material basis of chronic obstructive pulmonary disease.The further study of mucin provide scientific basis for explained “The spleen is the source of phlegm and the lung is the device for storing phlegm”.