Shuangshen Decoction In The Treatment Of Cough Cough After Infection(Wind Cough Syndrome) Clinical And Experimental Study

Objective:To evaluate the clinical effect and clinical curative effect of the tutor's experience on the treatment of post infectious cough(wind cough).Method:1:through literature research in the past ten years(2006?2016)related cough after infection and the wind cough syndrome in reading articles and analysis,summarizes the modern medicine,pathogenesis,treatment and prognosis of cough syndrome,wind source,treatment and clinical treatment,in-depth analysis of cough after infection with the wind cough syndrome contact.This paper reviews the existing problems in the recognition and treatment of cough after infection.2 animal experiment:the ammonia induced cough in mice model of 110 rats were randomly divided into model group,Suhuang capsule of traditional Chinese medicine group,western medicine group,clarityne Shuangshen prescription Decoction group 1 of the 4 dose group,the prescription of Shuangshen Decoction and tutor of 2 of the 4 dose groups(2 times,1 times,1/2 times and 1/4 times respectively in clinical dose)with 10 rats in each group of mice,the first cough time(incubation period),the number of 3 minutes of cough were recorded for statistical analysis.The ovalbumin induced allergic bronchospasm guinea pig model of 120 rabbits were randomly divided into control group,model control group,Suhuang capsule of traditional Chinese medicine group,western medicine group,clarityne Shuangshen prescription Decoction group 1 of the 4 dose group,the prescription of Shuangshen Decoction and tutor of 2 of the 4 dose groups(respectively,equivalent to clinical dose 2 times,1 times,1/2 times,1/4 times)with 10 rats in each group of guinea pigs,self stop spraying into asthmatic convulsions of the time(incubation period),and the number of animal falls with shock records,the results were statistically analyzed3 clinical trials:60 patients with post infectious cough wind cough syndrome criteria,according to a simple random grouping method is divided into two groups:30 cases in the experimental group,the tutor experience "Shuangshen oral antitussive Decoction;the control group of 30 cases,treated with" Robitussin(Pseudoephedrine Hydrochloride Chlorphenamine Maleate and Dextromethorphan Hydrobromide Solution)"treatment.The course of treatment was two weeks.Observation of the two groups of patients before and after treatment of TCM syndrome score,using SPSS 19.0 statistical analysis,comparison of two groups of curative effect difference.Results:1 the literature summarizes the understanding of the traditional Chinese medicine and Western medicine in the treatment of cough and cough after infection,but there are still the following problems:modern medicine:(1)there is no accepted standard in the world.(2)lack of physical and chemical indicators with diagnostic significance.(3)symptomatic treatment,the side effects were obvious.(4)a unified index without efficacy evaluation.Traditional Chinese medicine:(1)there is no consensus on the attribution of the disease.(2)the lack of unified TCM syndrome observation index.(3)there is no consistent treatment plan(4)most of the combination of traditional Chinese and Western medicine treatment is not very mature,mostly simple mechanical combination of traditional Chinese medicine and Western medicine treatment.2 through the animal experiment,1 and 2 in the prescription prescription dosage range of ammonia induced cough in mice with ovalbumin model and decrease the frequency of cough and prolong the cough incubation period of guinea pig model induced bronchospasm.The model of cough induced by ammonia effect is better than the prescription prescription 2 1,and 2 times the prescribed dose group compared with model group,the difference was statistically significant(P<0.05);to ovalbumin induced bronchial spasm in guinea pig model is slightly better than the 1 Prescription prescription 2,but compared with the model group,there was no statistically significant difference.The optimal dose of the two prescriptions was basically equal to the clinical dose.3 clinical trial results:1)the main symptoms of cough in two groups after treatment,secondary symptoms of throat itching,shortness of breath and TCM syndrome score were improved compared with before treatment(P<0.05).2)compared with the control group,after treatment for 2 weeks,the experimental group was significantly improved in cough,pharyngeal itching and TCM syndrome score(P<0.05).3)the clinical efficacy of the two groups,after 2 weeks of treatment,the control effective rate of test group was 70%,the total effective rate was 100%;the control group control rate was 33.3%,the total effective rate was 96.7%,the total efficiency of the two groups compared to the difference was statistically significant,and the efficacy of the experimental group than the control group(P<0.05).Conclusion:it is concluded that both of the two methods are effective in the animal experiment and clinical observation.