Clinical Observation Of Wengyang Tongluo External Prescription In The Treatment Of Type 2 Diabetes Mellitus Patients With Knee Osteoarthritis

ObjectiveThrough observing the clinical practice of Wenyang Tongluo prescription in treating type 2 Diabetes Mellitus patients with Knee Osteoarthritis,to found out the clinical effect of this therapy on Chinese medicine syndrome,visual analogue scale,Western Ontario and Mc Master Universities osteoarthritis index and blood glucose.Security was also observed.To explore the mechanism preliminary,the study also aimed to provide objective foundations for using external herbs of Traditional Chinese Medicine dialectically to treat patients with T2DM and KOA in clinical pratice.MethodsBased on the selection criteria,40 patients were selected and randomly divided into treatment group and control group,each with 20 patients.Patients were all given conventional therapy and the control group was treated with Votalin Emulgel per day.The treatment group was treated with Wenyangtongluo herbs fomentation 30 minutes/time per day.At 1 week after treatment,the changes of clinical symptom,VAS grade,WOMAC grade,blood glucose and the differences in side effect in the 2 groups were compared.Resulis(1)TCM syndrome score:After the treatment,Both treatments were effective in reducing sign and symptom of T2DM patients with knee osteoarthritis(P<0.05).However the scores of treatment group decreased more significantly.The treatment group(total effective rate was 89.47%)was superior to the control group(total effective rate was 44.44%),which showed statistical difference(P<0.05).(2)VAS score:Both treatments were effective in reducing reducing VAS scores(P<0.05),the comparison between two groups showed no significant difference.(3)WOMAC score:Both treatments were effective in reducing reducing WOMAC scores(P<0.05),the treatment group was more effective to the control group(P<0.05).(4)Blood glucose:The levels of 2h post-breakfast blood glucose(2hPG)both reduced in two groups,but there was no significant difference between two groups(P>0.05).The levels of 2h post-suppert blood glucose(2hPG)were significantly lower in treatment group than those of control group(P<0.05).(5)Security analysis:There were no obvious side effects showed,such as skin allergy,sever hepatic and renal dysfunction,aggravating or causing cardiovascular and cerebrovascular disease,and so on.ConclusionThe therapy with Wenyangtongluo herbs fomentation was effective for T2DM patients with knee osteoarthritis without obvious side effects.Clinical symptom,physical sign had improved,as well as pain score decreased.So it deserves to be explored and used further in clinical practice.