The Research About Patients With Crohn's Disease In Activity Period Of TCM Syndrome Factor

ObjectiveTo investigate the TCM syndrome factors and characteristics in Crohn's disease during the active period,analyize on the characteristics of the level of syndrome factors and diagnostic elements in Crohn,s disease.This study may provide some suggestions about the treatments,giving a clear syndrome differentiation in Crohn,s disease.Methods50 patients were collected in Guangdong Province of TCM hospital.According to the standardised syndrome factor scale,these patients' symptoms were recorded and analysed to give the syndrome characteristics of active Crohn's disease patients.Results1.Among the 50 patients of Crohn' s disease during the active period,31 were males(62%),19 were females(38%),43 were young patients,5 were middle aged,while 2 were elderly.Clinically,these patients were having symptoms like diarrhea(60%),abdominal pain(78%),ventosity and mucus seen in stool(14%).There were other complications like anal fistula(32%),perianal abscess(18%),fever(12%).The main inducing factors were diets(30%),emotions(10%),fatigue(20%).2.According to the syndrome factor grading standard,50 patients with Crohn's disease during active period have met the requirements of 10 disease locations.They were namely spleen,large intestine,stomach,small intestine,skin,liver,kidney,lower abdomen,bones and gall bladder.For the disease factor characteristics,15 kinds has met the classification standard.They were qi deficiency,blood deficiency,dampness,yang deficiency,qi stagnation,blood stasis,poison,pus,haemorrhage,heat,yin deficiency,phlegm,dyspepsia and cold.3.According to the diagnostic standard of syndrome factors,there were 6 disease locations with diagnostic values,which were spleen,large intestine,stomach,small intestine,skin and bone.The main disease locations were in spleen,large intestine and stomach.In addition,there were 12 syndrome factors with diagnostic values,namely qi deficiency,blood deficiency,dampness,yang deficiency,qi stagnation,blood stasis,poison,pus,haemorrhage,heat,yin deficiency,phlegm.The main syndrome factors were qi deficiency,blood deficiency,yang deficiency,dampness and qi stagnation.4.For the distribution of the diagnostic factors within the different genders,the disease location includes spleen,stomach and large intestine,were equally seen in both genders,but males seen more cases of disease location in small intestine.The gender distribution in the syndrome factors was equal.The distribution of disease duration and disease location factors,spleen as the disease location was observed in different disease stages.During 3 to 9 years of Crohn's disease,the disease locations were mainly spleen and stomach.Small intestine,as a disease location,was seen in first 1-2 years and 3-9 years in the disease course.Skin,as a disease location,was seen in less than 2 years in the disease course,while bone was seen in more than 10 years in the disease course.During the different stages of disease,the syndrome factors,such as dampness,qi deficiency,blood deficiency and yang deficiency,were observed.During 3 to 9 years of Crohn's disease,qi deficiency,blood deficiency,yang deficiency,qi stagnation,blood stasis and phlegm were mainly observed.To relate the different severity of this disease with disease locations,it was seen that spleen,stomach and large intestine were identified regardless the disease was mild or severe.The relationship between syndrome factors and disease severity was also identified.Pus,heat and yin deficiency was seen more in moderate to severe patients.Haemorrhage seen in mild and severe patients,while 2 cases of phlegm in moderate patients.ConclusionCrohn's disease is mainly seen in young patients.Disease-inducing factors,such as diets,emotions and fatigue.Main clinical symptoms were abdominal pain,diarrhea,ventosity,mucus stool,and sometimes anal fistula and perianal abscess.In syndrome factor classification,primary and secondary syndrome factors have the diagnostic values.The corresponding disease locations were spleen,stomach,large intestine,small intestine,skin and bone.The corresponding syndrome factors were qi deficiency,blood deficiency,yang deficiency,yin deficiency,dampness,qi stagnation,blood stasis,poison,pus,haemorrhage,heat,phlegm.