Correlation Between Serum Galetin-3、Inflammatory Factors And The Severity Of Coronary Lesion And Major Adverse Cardiac Events

Objective To observe the serum levels of Galetin-3、Hs-CRP、IL-6 and TNF-a,and discuss the correlation between those indicators and the severity of Coronary lesion and major adverse cardiac events(MACE).Methods Select 180 patients as the object of the study.According to the Coronary angiography into positive CHD group(126 patients)and the negative control group(54 126 patients).In group of CHD,according to different vascular count divided into the single lesion group(54 patients)、the double lesion group(40patients)and the multivessel lesions group(30 patients).The group of CHD were divided into the mild stenosis group(51 patients)and the severe stenosis group(75 patients).According to the Gensini score to rate all research objects.Then follow-up all patients with coronary heart disease on phone or outpatient for a period of 30 days,recording major adverse cardiac events in all coronary heart disease(mainly including angina pectoris,myocardial infarction,heart failure,cardiac dead and so on).Serum levels of Gal-3、Hs-CRP、IL-6 and TNF-a were detected in all patients,to analyze the correlation between those indicators and the severity of Coronary lesion and MACE.Results 1.Serum levels of Gal-3 and inflammatory factors of the coronary heart disease group were significantly increased compared with the control group(P<0.01).2.Serum levels of Gal-3 and Inflammatory factors in the multi-vessel disease group higer than that of the double-vessel disease group、the single-vessel disease group and the control group(P<0.05);the double-vessel disease group higer than that of the single-vessel disease group and the control group(P<0.05);the single-vessel disease group higer than that of the control group(P<0.05).3.The severe coronary disease stenosis group were significantly higer than that of the mild coronary disease stenosis group and the control group(P<0.05);the mild corona-ry disease stenosis group higer than that of the control group(P<0.05).4.Serum levels of Gal-3、Inflammatory factors and Gensini scores were positively correlated(r=0.639、0.553、0.267、0.211,P<0.01,P<0.05).5.Compared with the without MACE patients,Serum levels of Gal-3、Inflammatory factors were significantly higher with MACE(P<0.05).Conclusion 1.The serum levels of Gal-3 and Hs-CRP、IL-6、TNF-a、Gensini scores in patients with coronary heart disease were significantly increased,serum Gal-3 have great potential to become effective clinical indicators.2.The serum levels of Gal-3 in patients with coronary heart disease could be used to preliminary predict the severity of coronary artery disease and evaluate the short-term prognosis of patients with coronary heart disease.