Clinical Observation Of Platelet-rich Plasma And Sodium Hyaluronate Acid Intra-articular Injection In The Treatment Of Knee Osteoarthritis

Objective: To study the effects of autologous plasma and platelet rich glass acid sodium were intra-articular injection therapy,antologous comparison of knee joint score index related to the curative effect of injection treatment with celecoxib in the treatment of knee osteoarthritis and platelet therapy combined with sodium hyaluronate intra-articular,objective and scientific evaluation of autologous platelet rich plasma combined with hyaluronic acid the clinical effect and application value of sodium,provide a safe and effective method for the treatment of osteoarthritis of the knee.Patients and methods: from December 2015 December-2016 year in Guangxi orthopedics hospital of knee osteoarthritis patients,a total of 120 cases.Using random number table cases according to the random number group,patients were randomly assigned to celecoxib group(group A),sodium hyaluronate group(B group),group(platelet rich plasma C group),combined treatment group(group D)were divided into 4 groups,30 cases in each group,were observed.Clinical trials of treatment for 30 cases of celecoxib group were 30 cases of oral Celecoxib Capsules,sodium hyaluronate group of patients using the knee injection of sodium hyaluronate for treatment,platelet rich plasma methods 30 cases of patients with group antologous platelet plasma was injected into the knee joint were treated,30 cases of combined treatment group were treated with autologous platelet rich plasma before and after treatment in.4 group were treated with the following intra-articular injection of sodium hyaluronate To facilitate the observation of clinical curative effect in the treatment of knee joint pain index score(VAS),knee osteoarthritis severity score(WOMAC),the International Knee Score(IKDC),knee osteoarthritis severity index score(Lequesne),ESR,C-reactive protein detection.The data acquisition and detection and using SPSS22.0 statistical software,statistical analysis of the data,and then draw conclusions.Results: the score of the knee joint: 4 groups of patients had no statistical significance in the treatment of knee joint pain score,IKDC score,WOMAC score,Lequesne index score difference(P > 0.05),1 months after treatment,3months,6 months VAS score of each group were lower than those before treatment(P < 0.05)D;group VAS patients were lower than those of the other3 groups,B group and C group patients VSA score lower than the A group,C group of patients with VAS were lower than those of group B(P < 0.05),the difference was statistically significant.1 months after treatment,3 months,6months,IKDC scores were higher than those before treatment(P < 0.05),D treatment in patients with IKDC score higher than the other 3 groups,B group and C group patients IKDC score higher than that of A group,C group of patients with IKDC score higher than that of B group(P < 0.05)statistically the difference.1 months after treatment,3 months,6 months,WOMAC scores were lower than those before treatment(P < 0.05),D treatment group patients with WOMAC score than the other 3 groups,B group and C group patients WOMAC score lower than the A group,C group of patients with WOMAC were lower than those of group B(P < 0.05),with statistically significant difference.1 months after treatment,3 months,6 months Lequesne index was lower than that before treatment(P < 0.05),group D patients with Lequesne index lower than the other 3 groups,B group and C group patients Lequesne index lower than that of group A,Lequesne index in C group was lower than that of group B(P < 0.05),the difference has statistical significance.4 groups of patients before treatment,ESR,C reactive protein concentration difference between the five was statistically significant(P > 0.05),after treatment compared with before treatment,the difference was statistically significant ESR and C-reactive protein concentrations of C(P < 0.05),after treatment,D group patients treated with ESR,C reactive protein concentration was lower than the other 3 group,B group and C group patients erythrocyte sedimentation rate,C reactive protein concentration was lower than A group,C group of patients with ESR,C reactive protein concentration was lower than B group(P < 0.05),with statistical significance.Conclusion:1.autologous platelet rich plasma combined with intra-articular injection of sodium hyaluronate therapy can significantly improve patients with knee osteoarthritis patients,reduce joint pain effectively,improve the function,curative effect,excellent oral and Celecoxib Capsules,pure sodium hyaluronate or pure autologous platelet rich plasma for intra-articular injection.2.knee intraarticular injection of sodium hyaluronate or autologous platelet rich plasma for knee osteoarthritis has certain curative effect,can reduce knee pain and improve knee function,including autologous platelet rich plasma injection is better than sodium hyaluronate.3.autologous platelet rich plasma combined with sodium hyaluronate knee joint cavity injection in the treatment of knee osteoarthritis in the test did not have adverse reactions,the treatment is safe and reliable,worthy of popularization and Application.