| ObjectiveOsteoarthritis is a common in pain and loss of activity of joint disorders which In articular cartilage degeneration and the subchondral bone changes of osteophyte formation and synovitis in pathological characteristics.Among them the occurring rate of knee joint is the highest. Knee osteoarthritis is refers to the knee joint cartilage of primary or secondary degeneration and structure of the disorder,With the subchondral bone hyperplasia, cartilage peeling, and Make joint destruction, deformity gradually. Eventually lead to a degenerative disease of the knee joint dysfunction.Osteoarthritis causes pain and disability seriously affected the quality of life of patients.In recent years, the incidence of knee osteoarthritis increased year by year.In particular are a danger to the elderly health of chronic progressive osteoarthropathy,which has become one of the main diseases of the elderly disabled.In clinic, we adopt articular cavity injection of sodium hyaluronate and Cooperate with injection of autologous platelet rich plasma treatment to Treat knee osteoarthritis.We have made a good therapeutic effect. In order to clarify the treatment may be the mechanism of action. We carry out’sodium hyaluronate injected with autologous platelet rich plasma injection in the treatment of knee osteoarthritis clinical and experimental research on project.Methods1in clinical researchCollection in December2012to September2013,60patients with knee osteoarthritis, Aged45-75,21cases were male,female39cases, Course of6months to3years, Randomly divided into group of platelet rich plasma,group of sodium hyaluronate and joint group. Cases in each group,18cases for statistics and research.All cases in accordance with the orthopaedic society of the diagnosis and treatment of osteoarthritis guide.After five months of follow-up.2Experimental study: 40rabbits were randomly devided into fivegroups, and the rabbitt models of KOA were induced by abscising medial col lateral ligament、medial meniscus angulus anterior and anterior cruciate ligament.After it, the blank group and the model group were treated by nothing and the positive control group were treated by Sodium Hya luronate(HA)injection of articular cavi. To the weekend,9pumping experiment animal heart blood, Detect tumor necrosis factor, IL-I. Put to death the experimental rabbit, open the risk of knee articular cartilage, slice, then observe the changes of articular cartilage.Results1Clinical studies have confirmed that A joint group of effective rate of95%for the treatment of knee osteoarthritis, Intra-articular injections of sodium hyaluronate in treatment group (HA) treatment of knee osteoarthritis.The effective rate was85%, Injection of autologous platelet rich plasma treatment group effective rate of for the treatment of knee osteoarthritis75%; After Ridit analysis, combined treatment group is better than that of HA and the PRP group.2Three methods can improve the clinical symptoms of knee osteoarthritis, reduce joint pain and improve joint function, Through statistical analysis confirmed^that the joint treatment group is better than that of HA and the PRP group.3Intra-articular injections of sodium hyaluronate treatment with intra-articular injection of autologous platelet rich plasma treatment, also used in the treatment of knee osteoarthritis with synergy.Experimental study confirmed:Intra-articular injections of sodium hyaluronate with injection of autologous platelet rich plasma treatment of knee osteoarthritis, can significantly reduce the levels of inflammatory markers white rabbit knee osteoarthritis, reduce inflammation reactions(p<0.01), Delay the destruction of articular cartilage.Intra-articular injections of sodium hyaluronate treat knee joint osteoarthritis, can significantly reduce the levels of inflammatory markers white rabbit knee osteoarthritis, reduce inflammation reactions(p<0.01), Delay the destruction of articular cartilage.Injection of autologous platelet rich plasma treatment of knee osteoarthritis, can significantly reduce the levels of inflammatory markers white rabbit knee osteoarthritis, reduce inflammation reactions(p<0.01), Delay the destruction of articular cartilage. 4after statistical analysis confirmed that the combined treatment group is better than that of HA and the PRP group.ConclusionClinical studies confirmed that, Intra-articular injections of sodium hyaluronate injection of autologous platelet rich plasma treatment and Intra-articular HA injection treatment, Can significantly reduce joint pain, improve joint function, relieve the clinical symptoms。The combined treatment group is better than that of HA and the PRP group.The experimental results show that, In the process of knee osteoarthritis pathological changes, there may be many factors involved in the pathogenesis. Intra-articular injections of sodium hyaluronate in cooperate with injection of autologous platelet rich plasma experiments for the treatment of knee osteoarthritis, The experimental data clearly show that intra-articular injections of sodium hyaluronate injection of autologous platelet rich plasma treat, Can significantly reduce the inflammatory factors, delay the destruction of articular cartilage, the articular cartilage of the knee osteoarthritis has a protective effect, And the curative effect is superior to the simple intra-articular injections of sodium hyaluronate and pure injection of autologous platelet rich plasma, Prove that injection of autologous platelet rich plasma treatment and the treatment of intra-articular HA injection, also used in the treatment of knee osteoarthritis with synergy. May be by reducing inflammation, lubrication and improve the clinical symptoms of articular cartilage. |
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