Study On The Correlation Between Liver Stiffness Measurement And TCM Syndromes In Patients With Hepatitis B Cirrhosis Compensatory Period Based On Fibrotouch

Objective:To explore the value of liver stiffness measurement(LSM)based on FibroTouch detection in the clinical diagnosis of hepatitis B cirrhosis compensatory period,and to study the value of LSM and three common TCM syndromes(liver qi stagnation,Dampness and heat accumulation,blood stasis)correlation,with a view to quantitative indicators to determine the type of hepatitis B cirrhosis patients with syndromes,enrich the objective of TCM syndrome differentiation,while increasing the efficacy of traditional Chinese medicine based on the judge.Methods:Collected in February 2016-February 2017,Fujian Province,the Second People's Hospital outpatient and physical examination center in line with the diagnostic criteria,included in the standard hepatitis B cirrhosis compensatory period patients in 90 cases,including liver qi stagnation syndrome,damp heat syndrome,stasis Blood stasis syndrome in 30 cases,and from the physical examination of health management center 30 cases as the normal control group,Men and women(n=15).To collect the patient's name,gender and other basic information and TCM four diagnostic data,with reference to the 2011 development of"cirrhosis of Chinese and Western medicine diagnosis and treatment consensus"for syndrome differentiation;the LSM values of patients were detected by FibroTouch,and the blood routine,biochemical,HBV-DNA,coagulation and ultrasonography were examined.Analyzed the correlation between LSM and TCM syndromes,APRI and other related indexes of hepatitis B cirrhosis compensatory.period by SPSS20.0 software.Results:1.The differences of LSM between the each group were statistically significant(P<0.05).Compared to normal control group with the card type group,the difference had statistical significance(P<0.05).There was significant difference between the liver qi stagnation group and other two groups(P<0.05).There was significant difference between the ldamp-heat group and blood stasis group(P<0.05).LSM was the highest in the blood stasis group,followed by the damp-heat group and the liver qi stagnation group.2.The APRI scores were statistically different in each groups(P<0.05).Compared to normal control group with the card type group,the difference had statistical significance(P<0.05).There was significant difference between the liver qi stagnation group and other two groups(P<0.05).The difference between the damp-heat group and the stagnation group was statistically significant(P<0.05).The nunerical comparison of liver qi stag:nation group<damp heat accumulation group<blood stasis group.3.Using Pearson correlation analysis,LSM was positively correlated with APRI score,Pearson correlation coefficient r=0.551,P=0.000.Conclusions:1.There are differences between different TCM syndromes of LSM detected by FibroTouch in the decompensated phase of hepatitis B cirrhosis compensatory period.And the LSM can be used as a reference index for TCM syndrome differentiation.2.LSM and APRI score in the assessment of early liver cirrhosis has a good correlation;FibroTouch as a simple and accurate noninvasive liver fibrosis diagnosis technology,has a high clinical value.