Cognitive Dysfunction Characteristics Of Elderly Patients With Acute Cerebral Infarction And Its Relationship With Plasma Pro-BNP And CRP Levels In Acute Stage

PurposeTo discuss the characteristics of cognitive dysfunction in elderly acute cerebral infarction and its relationship with acute phase plasma brain natriuretic peptide precursor(pro-BNP)and c-reactive protein(CRP)level,so as to provide basis for the prevention and treatment of elderly acute cerebral infarction cognitive dysfunction.Methods44 cases of elderly acute cerebral infarction within 48 h onset in our hospital from January 2014 and January 2015 were selected as observation group,and the other 30 cases of the elderly healthy persons had physical exam in the same period selected as the control group.The brain MRI and DWI confirmed infarction lesion size,number and position,clinical data,plasma pro-BNP and CRP levels,Montreal cognitive assessment scale(Mo CA)and the United States national institutes of health stroke scale(NIHSS)scores of the two groups were statistically analyzed,and Pearson correlation analysis was applied in the analysis of relationship between cognitive function in elderly acute cerebral infarction and acute phase plasma pro-BNP and CRP levels.Results1.Compared with the control group and remission stage of observation group,acute phase NIHSS score of observation group was significantly increased,while Mo CA score of observation group was decreased significantly,and the difference was statistically significant(P < 0.05).2.The observation group acute phase plasma pro-BNP and CRP levels were significantly higher than that of control group and remission stage of observation group,and the difference was statistically significant(P <0.05).3.There were significant differences in plasma pro-BNP and CRP levels in patients with different degrees of cerebral infarction(P<0.05).4.Different degrees of nerve injury in patients with acute cerebral infarction between pro-BNP and CRP levels were statistically significant(P<0.05).5.In the observation group,32 patients had cognitive dysfunction,and the incidence of cognitive dysfunction was 72.73%(32/44).Plasma BNP and CRP level of patients with cognitive dysfunction(Mo CA < 26 points)were higher than that of patients without cognitive dysfunction(Mo CA? 26 points)the difference was statistically significant(P < 0.05).6.Pearson correlation analysis results showed that the plasma pro-BNP and CRP levels in elderly acute cerebral infarction were negatively correlated with Mo CA score(r=-0.803,-0.639,P <0.05),while positively correlated with NIHSS score(r=0.908,0.824,P<0.05).Conclusion1.Elderly patients with acute cerebral infarction have high cognitive dysfunction occurrence.2.The plasma Pro-BNP and CRP levels of elderly patients with acute cerebral infarction are high.3.The occurrence of cognitive dysfunction in elderly patients with acute cerebral infarction and its plasma pro-BNP and CRP levels were related,elderly acute cerebral infarction showing high plasma pro-BNP and CRP levels should be on guard against the cognitive dysfunction.