| Objectives: To observe the clinical curative effect and safety of TCM prescription(soothing Liver strengthening spleen activating blood)combining with western medicine in treating alcoholic cirrhosis(AC)and to discuss the rationality of using this method theoretically and clinically.With the objective of promoting experience and methods of treating alcoholic cirrhosis,it is to provide beneficial reference for clinical treatment.Methods: 62 patients with alcoholic cirrhosis were randomly divided into two groups: the observation group and the control group(31 cases in each group).Patients from both groups were given treatments including temperance,nutritional support,liver protection,etc.The treatment method of soothing liver strengthening spleen activating blood was adopted in the observation group,using Chai shao Liu jun decoction and Ge xia zhu yu concoction combining with polyene phosphatidylcholine capsule treatment,and the control group adopted polyene phosphatidylcholine capsule treatment.Twelve weeks were taken as one treatment course.After treatment,symptoms and sign score changes,serum biochemical indices(AST,ALT,ALB,TBIL,GGT),serum liver fibrosis indexes(HA,PCⅢ,Ⅳ-C,LN)and abdominal B ultrasound(intrahepatic portal vein diameter,thickness of spleen)changes of two groups were recorded to compare the curative effect.Results:1.1 case in both observation group and control group were excluded during research,and altogether 60 cases were enrolled in the research eventually.Differences in general information,such as sex,age,course of disease and illness between two groups were not statistically significant(P>0.05);therefore,they were comparable.2.Improvements in costalgia,abdominal distention,poor appetite,weakness,emotion,jaundice and splenomegaly in observation group were remarkably superior to those in control group after treatment(P<0.05);but differences in loose tool and hepatic facies between two groups after treatment were not statistically significant(P>0.05).When comparing the therapeutic effects on symptoms and signs between observation group and control group,the overall response rate in observation group was 83.33%,while that in control group was 66.67%,with difference being of statistical significance(P<0.05).It suggested that observation group showed distinct advantages in improving symptoms and signs.3.Liver functions(AST,ALT,TBIL and GGT),hepatic fibrosis indexes(HA,PCⅢ,Ⅳ-C and LN)and changes in spleen thickness in observation group were superior to those in control group upon the completion of treatment course(P<0.05).Liver function ALB was elevated in both groups after treatment,but the difference was not statistically significant(P>0.05).Main portal vein inner diameter in both groups,as well as spleen thickness in control group before and after treatment showed no statistical significance(P>0.05).4.Overall response rate in observation group after 12 weeks of treatment was 86.67%,while that was 70.00% in control group,and difference in therapeutic effects between two groups was statistically significant(P<0.05).5.During the period of 12 weeks of clinical research,two groups of patients before and after treatment of safety inspection program did not appear abnormal,observation group the incidence of adverse reactions was 13.33%,less than 33.33% of the control group,suggesting this study(P < 0.05),the clinical efficacy of good safety.Conclusions: Based on liver spleen and activating blood method to guide the clinical curative effect is better than that of control group,and no obvious adverse reaction,high safety,with further research,development and application of value. |
